Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 16 studies | 34% ± 15% | |
fibroblast | 15 studies | 27% ± 12% | |
basal cell | 13 studies | 40% ± 14% | |
endothelial cell of lymphatic vessel | 12 studies | 36% ± 15% | |
smooth muscle cell | 9 studies | 29% ± 11% | |
endothelial cell of vascular tree | 7 studies | 25% ± 10% | |
connective tissue cell | 7 studies | 32% ± 16% | |
myofibroblast cell | 6 studies | 25% ± 9% | |
epithelial cell | 6 studies | 40% ± 11% | |
mesothelial cell | 4 studies | 30% ± 16% | |
endothelial cell | 4 studies | 29% ± 7% | |
secretory cell | 4 studies | 45% ± 10% | |
pancreatic A cell | 3 studies | 22% ± 2% | |
luminal cell of prostate epithelium | 3 studies | 27% ± 10% | |
glial cell | 3 studies | 32% ± 15% | |
vein endothelial cell | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 2034.00 | 180 / 180 | 93% | 43.67 | 399 / 430 |
uterus | 100% | 5372.35 | 170 / 170 | 89% | 46.88 | 407 / 459 |
prostate | 100% | 3976.94 | 245 / 245 | 85% | 23.90 | 429 / 502 |
esophagus | 100% | 4992.54 | 1445 / 1445 | 79% | 42.87 | 145 / 183 |
breast | 90% | 2724.96 | 413 / 459 | 73% | 20.41 | 820 / 1118 |
thymus | 82% | 1037.71 | 534 / 653 | 81% | 118.35 | 490 / 605 |
skin | 100% | 3617.71 | 1809 / 1809 | 57% | 47.73 | 268 / 472 |
bladder | 100% | 4363.95 | 21 / 21 | 56% | 18.84 | 280 / 504 |
intestine | 89% | 4611.79 | 864 / 966 | 46% | 10.65 | 242 / 527 |
lung | 49% | 595.07 | 283 / 578 | 74% | 27.57 | 860 / 1155 |
stomach | 58% | 1934.79 | 208 / 359 | 59% | 12.50 | 169 / 286 |
blood vessel | 99% | 3080.81 | 1326 / 1335 | 0% | 0 | 0 / 0 |
kidney | 67% | 1105.52 | 60 / 89 | 28% | 10.28 | 249 / 901 |
pancreas | 3% | 30.43 | 10 / 328 | 91% | 43.62 | 162 / 178 |
adipose | 91% | 1550.61 | 1097 / 1204 | 0% | 0 | 0 / 0 |
brain | 51% | 637.63 | 1357 / 2642 | 37% | 23.61 | 259 / 705 |
tonsil | 0% | 0 | 0 / 0 | 84% | 59.48 | 38 / 45 |
adrenal gland | 12% | 130.21 | 31 / 258 | 65% | 46.12 | 150 / 230 |
heart | 57% | 1679.70 | 488 / 861 | 0% | 0 | 0 / 0 |
spleen | 27% | 228.63 | 64 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 24% | 4.10 | 7 / 29 |
eye | 0% | 0 | 0 / 0 | 8% | 1.10 | 6 / 80 |
muscle | 5% | 48.11 | 43 / 803 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 3% | 0.84 | 12 / 406 |
peripheral blood | 1% | 14.29 | 12 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007507 | Biological process | heart development |
GO_0061061 | Biological process | muscle structure development |
GO_0098976 | Biological process | excitatory chemical synaptic transmission |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0005856 | Cellular component | cytoskeleton |
GO_0031941 | Cellular component | filamentous actin |
GO_0043197 | Cellular component | dendritic spine |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0030018 | Cellular component | Z disc |
GO_0034777 | Cellular component | recycling endosome lumen |
GO_0031901 | Cellular component | early endosome membrane |
GO_0055038 | Cellular component | recycling endosome membrane |
GO_0001725 | Cellular component | stress fiber |
GO_0005912 | Cellular component | adherens junction |
GO_0031905 | Cellular component | early endosome lumen |
GO_0005737 | Cellular component | cytoplasm |
GO_0045211 | Cellular component | postsynaptic membrane |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0019903 | Molecular function | protein phosphatase binding |
GO_0051371 | Molecular function | muscle alpha-actinin binding |
GO_0051393 | Molecular function | alpha-actinin binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | PDLIM4 |
Protein name | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDZ and LIM domain protein 4 PDZ and LIM domain 4 isoform 1 PDZ and LIM domain 4 |
Synonyms | RIL |
Description | FUNCTION: [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle . Involved in reorganization of the actin cytoskeleton . In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). .; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. . |
Accessions | C9J542 A0A0S2Z4P0 ENST00000418373.1 P50479 ENST00000253754.8 [P50479-1] A0A0S2Z4N4 ENST00000379018.7 [P50479-2] |