PDLIM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007507Biological processheart development
GO_0061061Biological processmuscle structure development
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_0030036Biological processactin cytoskeleton organization
GO_0005856Cellular componentcytoskeleton
GO_0031941Cellular componentfilamentous actin
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030018Cellular componentZ disc
GO_0034777Cellular componentrecycling endosome lumen
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0001725Cellular componentstress fiber
GO_0005912Cellular componentadherens junction
GO_0031905Cellular componentearly endosome lumen
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0051371Molecular functionmuscle alpha-actinin binding
GO_0051393Molecular functionalpha-actinin binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePDLIM4
Protein namePDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)
PDZ and LIM domain protein 4
PDZ and LIM domain 4 isoform 1
PDZ and LIM domain 4
SynonymsRIL
DescriptionFUNCTION: [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle . Involved in reorganization of the actin cytoskeleton . In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). .; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. .

AccessionsC9J542
A0A0S2Z4P0
ENST00000418373.1
P50479
ENST00000253754.8 [P50479-1]
A0A0S2Z4N4
ENST00000379018.7 [P50479-2]