PDE5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060282Biological processpositive regulation of oocyte development
GO_0010749Biological processregulation of nitric oxide mediated signal transduction
GO_0048599Biological processoocyte development
GO_0019933Biological processcAMP-mediated signaling
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0055118Biological processnegative regulation of cardiac muscle contraction
GO_0055119Biological processrelaxation of cardiac muscle
GO_0042098Biological processT cell proliferation
GO_0046069Biological processcGMP catabolic process
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0005575Cellular componentcellular_component
GO_0005829Cellular componentcytosol
GO_0004114Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0030553Molecular functioncGMP binding

IV. Literature review

[source]
Gene namePDE5A
Protein namecGMP-specific phosphodiesterase PDE5A1
cGMP-specific phosphodiesterase PDE5A2
Uncharacterized protein PDE5A
Phosphodiesterase 5A
cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)
cGMP-specific phosphodiesterase PDE5A1 (cGMP-specific phosphodiesterase type 5A)
Phosphodiesterase (EC 3.1.4.-)
SynonymshCG_38154
PDE5
DescriptionFUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP . Specifically regulates nitric-oxide-generated cGMP . .

AccessionsENST00000264805.9 [O76074-2]
O76074
ENST00000354960.8 [O76074-1]
Q9P0K3
H0YA14
C9JGT3
Q9P0K6
Q9P0K5
ENST00000394439.5
Q4W5L4
ENST00000420633.1
G5E9C5
ENST00000503412.1
Q9P0K4