PAXBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006366Biological processtranscription by RNA polymerase II
GO_0014842Biological processregulation of skeletal muscle satellite cell proliferation
GO_2000288Biological processpositive regulation of myoblast proliferation
GO_0007517Biological processmuscle organ development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990226Molecular functionhistone methyltransferase binding

IV. Literature review

[source]
Gene namePAXBP1
Protein namePAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1)
PAX3 and PAX7 binding protein 1
SynonymsC21orf66
GCFC1
GCFC
DescriptionFUNCTION: Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). .

AccessionsENST00000421049.1
ENST00000445049.1
Q9Y5B6
ENST00000331923.9 [Q9Y5B6-1]
ENST00000290178.4 [Q9Y5B6-2]
H7C2W4
ENST00000573680.5
ENST00000574159.2
H7BZC8
ENST00000443785.5 [Q9Y5B6-4]