PAX4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PAX4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAX4 at tissue level.

III. Associated gene sets

GO_0048856Biological processanatomical structure development
GO_0030154Biological processcell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0003677Molecular functionDNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene namePAX4
Protein namePAX4 protein
Paired box gene 4
Paired box protein Pax-4
Paired box 4
SynonymshCG_33174
tcag7.68
DescriptionFUNCTION: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.

AccessionsJ3KPG0
ENST00000639438.3
ENST00000341640.6 [O43316-4]
A0A1W2PPX4
A4D0Z1
Q3KNR4
ENST00000378740.6
Q3KNR5
O43316