PASK | OmnibusX

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	11 studies	24% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	7 studies	26% ± 11%	Explore
T follicular helper cell	7 studies	36% ± 15%	Explore
regulatory T cell	6 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	30% ± 14%	Explore
T cell	3 studies	22% ± 1%	Explore
ciliated cell	3 studies	16% ± 1%	Explore
glutamatergic neuron	3 studies	22% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PASK at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	2573.07	245 / 245	100%	9.36	500 / 502
bladder	100%	558.57	21 / 21	97%	5.93	490 / 504
thymus	100%	2040.46	653 / 653	97%	38.13	584 / 605
uterus	99%	755.56	169 / 170	96%	6.94	441 / 459
breast	98%	774.55	451 / 459	96%	6.66	1076 / 1118
pancreas	99%	744.86	325 / 328	94%	4.55	168 / 178
lung	99%	1266.99	575 / 578	94%	5.83	1080 / 1155
skin	98%	1022.40	1773 / 1809	93%	5.34	440 / 472
intestine	95%	946.02	919 / 966	96%	5.82	505 / 527
stomach	96%	742.79	344 / 359	93%	5.74	266 / 286
ovary	100%	590.94	180 / 180	86%	4.75	368 / 430
esophagus	84%	581.58	1207 / 1445	97%	6.26	177 / 183
kidney	100%	1128.46	89 / 89	73%	3.07	656 / 901
brain	90%	1457.50	2376 / 2642	69%	2.74	486 / 705
adrenal gland	83%	323.84	215 / 258	32%	1.37	73 / 230
liver	68%	261.18	153 / 226	33%	1.31	136 / 406
lymph node	0%	0	0 / 0	100%	36.57	29 / 29
spleen	100%	1528.19	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	8.78	1 / 1
adipose	97%	533.49	1162 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	7.06	42 / 45
peripheral blood	82%	1869.66	758 / 929	0%	0	0 / 0
blood vessel	59%	222.27	785 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	45%	1.42	36 / 80
heart	35%	110.71	300 / 861	0%	0	0 / 0
muscle	10%	33.37	81 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0097009	Biological process	energy homeostasis
GO_0070092	Biological process	regulation of glucagon secretion
GO_0045719	Biological process	negative regulation of glycogen biosynthetic process
GO_0035556	Biological process	intracellular signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0043576	Biological process	regulation of respiratory gaseous exchange
GO_0045727	Biological process	positive regulation of translation
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0005515	Molecular function	protein binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0005524	Molecular function	ATP binding

Gene name	PASK
Protein name	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) PAS domain containing serine/threonine kinase
Synonyms	KIAA0135
Description	FUNCTION: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. .
Accessions	Q96RG2 ENST00000234040.9 [Q96RG2-1] ENST00000452907.1 ENST00000437780.5 ENST00000433589.5 ENST00000544142.5 [Q96RG2-1] ENST00000415234.1 C9J4R3 ENST00000403638.7 [Q96RG2-4] ENST00000405260.5 [Q96RG2-1] ENST00000358649.8 [Q96RG2-2] F8WEB4 ENST00000629419.1 H7C0L7 C9J1Z3

PASK report