PAFAH1B3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0006629Biological processlipid metabolic process
GO_0007399Biological processnervous system development
GO_0016042Biological processlipid catabolic process
GO_0008247Cellular component1-alkyl-2-acetylglycerophosphocholine esterase complex
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0044877Molecular functionprotein-containing complex binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0047179Molecular functionplatelet-activating factor acetyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAFAH1B3
Protein namePlatelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)
Platelet activating factor acetylhydrolase 1b catalytic subunit 3
1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47)
SynonymsPAFAHG
DescriptionFUNCTION: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. .

AccessionsM0R1K3
ENST00000594989.5
M0QZT2
M0R323
M0R389
ENST00000595530.5
ENST00000262890.8
Q15102
ENST00000538771.5
ENST00000599778.1
M0QXS6
ENST00000596265.5
ENST00000601865.5