OSBPL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006699Biological processbile acid biosynthetic process
GO_0006869Biological processlipid transport
GO_0032433Cellular componentfilopodium tip
GO_0005829Cellular componentcytosol
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0015485Molecular functioncholesterol binding

IV. Literature review

[source]
Gene nameOSBPL3
Protein nameOxysterol binding protein like 3
Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)
SynonymsORP3
OSBP3
KIAA0704
DescriptionFUNCTION: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes . Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface . With VAPA, may regulate ER morphology . Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion . Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 . Also binds 25-hydroxycholesterol and cholesterol . .

AccessionsC9JZ19
ENST00000409069.5 [Q9H4L5-4]
ENST00000409555.5 [Q9H4L5-8]
ENST00000415162.5
Q9H4L5
ENST00000415952.1
ENST00000396429.5 [Q9H4L5-3]
C9J8P4
ENST00000441059.5
ENST00000313367.7 [Q9H4L5-1]
ENST00000409452.5 [Q9H4L5-5]
ENST00000409863.5 [Q9H4L5-6]
ENST00000409759.5 [Q9H4L5-7]
C9JEF2
ENST00000396431.5 [Q9H4L5-2]