OSBPL10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036150Biological processphosphatidylserine acyl-chain remodeling
GO_0015914Biological processphospholipid transport
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_0005548Molecular functionphospholipid transporter activity
GO_0015485Molecular functioncholesterol binding

IV. Literature review

[source]
Gene nameOSBPL10
Protein nameOxysterol-binding protein
Oxysterol binding protein like 10
Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)
SynonymsORP10
OSBP9
DescriptionFUNCTION: Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis . Negatively regulates APOB secretion from hepatocytes . Binds cholesterol and acidic phospholipids . Also binds 25-hydroxycholesterol . Binds phosphatidylserine . .

AccessionsH7C487
ENST00000396556.7 [Q9BXB5-1]
ENST00000429492.6
A0A8V8TM06
A0A5F9ZH75
ENST00000438237.6 [Q9BXB5-2]
H7C199
Q9BXB5
ENST00000698199.1
ENST00000428241.1
ENST00000673388.1