ORC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051258Biological processprotein polymerization
GO_0006270Biological processDNA replication initiation
GO_0040038Biological processpolar body extrusion after meiotic divisions
GO_0000808Cellular componentorigin recognition complex
GO_0005664Cellular componentnuclear origin of replication recognition complex
GO_0005730Cellular componentnucleolus
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0003688Molecular functionDNA replication origin binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0000166Molecular functionnucleotide binding

IV. Literature review

[source]
Gene nameORC4
Protein nameOrigin recognition complex subunit 4
SynonymsORC4L
DescriptionFUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. .

AccessionsENST00000536575.5 [O43929-2]
ENST00000540442.5 [O43929-3]
ENST00000416719.5
C9J2X8
O43929
ENST00000392857.10 [O43929-1]
ENST00000264169.6 [O43929-1]
C9JGH7
ENST00000457954.5
Q53SE3
ENST00000440042.1
ENST00000535373.5 [O43929-1]