ORC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061351Biological processneural precursor cell proliferation
GO_0006270Biological processDNA replication initiation
GO_0006275Biological processregulation of DNA replication
GO_0006260Biological processDNA replication
GO_0014009Biological processglial cell proliferation
GO_0000808Cellular componentorigin recognition complex
GO_0005664Cellular componentnuclear origin of replication recognition complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0016604Cellular componentnuclear body
GO_0031261Cellular componentDNA replication preinitiation complex
GO_0005656Cellular componentnuclear pre-replicative complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003688Molecular functionDNA replication origin binding

IV. Literature review

[source]
Gene nameORC3
Protein nameOrigin recognition complex subunit 3 (Origin recognition complex subunit Latheo)
Origin recognition complex subunit 3
SynonymsLATHEO
ORC3L
DescriptionFUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. .

AccessionsU3KQL3
Q9UBD5
ENST00000508875.1
ENST00000546266.5 [Q9UBD5-3]
ENST00000392844.8 [Q9UBD5-1]
ENST00000257789.4 [Q9UBD5-2]