I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 7 studies | 86% ± 7% | |
| hepatocyte | 3 studies | 40% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 7 studies | 86% ± 7% | |
| hepatocyte | 3 studies | 40% ± 12% |
Insufficient scRNA-seq data for expression of ONECUT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 790.62 | 226 / 226 | 97% | 12.22 | 392 / 406 |
| pancreas | 100% | 845.55 | 328 / 328 | 54% | 2.95 | 97 / 178 |
| brain | 44% | 4.01 | 1153 / 2642 | 5% | 0.11 | 35 / 705 |
| skin | 14% | 0.84 | 253 / 1809 | 28% | 0.91 | 134 / 472 |
| stomach | 18% | 1.04 | 66 / 359 | 9% | 0.59 | 27 / 286 |
| lung | 10% | 0.51 | 58 / 578 | 16% | 0.56 | 185 / 1155 |
| adipose | 26% | 1.88 | 308 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 18% | 1.05 | 175 / 966 | 6% | 0.24 | 31 / 527 |
| esophagus | 17% | 1.05 | 252 / 1445 | 7% | 0.72 | 12 / 183 |
| breast | 22% | 1.49 | 101 / 459 | 1% | 0.02 | 13 / 1118 |
| bladder | 19% | 0.86 | 4 / 21 | 3% | 0.06 | 13 / 504 |
| heart | 21% | 1.29 | 185 / 861 | 0% | 0 | 0 / 0 |
| ovary | 14% | 0.72 | 26 / 180 | 1% | 0.11 | 5 / 430 |
| uterus | 12% | 0.65 | 21 / 170 | 3% | 0.14 | 14 / 459 |
| thymus | 15% | 0.84 | 99 / 653 | 0% | 0.01 | 1 / 605 |
| kidney | 13% | 1.00 | 12 / 89 | 2% | 0.06 | 14 / 901 |
| prostate | 13% | 1.01 | 33 / 245 | 0% | 0 | 0 / 502 |
| blood vessel | 12% | 0.64 | 158 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 6% | 0.28 | 16 / 258 | 0% | 0.01 | 1 / 230 |
| peripheral blood | 4% | 0.48 | 40 / 929 | 0% | 0 | 0 / 0 |
| spleen | 4% | 0.66 | 10 / 241 | 0% | 0 | 0 / 0 |
| muscle | 2% | 0.12 | 20 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0003309 | Biological process | type B pancreatic cell differentiation |
| GO_0060271 | Biological process | cilium assembly |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0003311 | Biological process | pancreatic D cell differentiation |
| GO_0001889 | Biological process | liver development |
| GO_0003310 | Biological process | pancreatic A cell differentiation |
| GO_0001952 | Biological process | regulation of cell-matrix adhesion |
| GO_0048536 | Biological process | spleen development |
| GO_0007492 | Biological process | endoderm development |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0016477 | Biological process | cell migration |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0002064 | Biological process | epithelial cell development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003682 | Molecular function | chromatin binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| Gene name | ONECUT1 |
| Protein name | One cut homeobox 1 Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1) |
| Synonyms | HNF6 HNF6A |
| Description | FUNCTION: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. |
| Accessions | U3KQR8 ENST00000570208.2 ENST00000305901.7 Q9UBC0 B2CNW3 |
