OAZ2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_1902268Biological processnegative regulation of polyamine transmembrane transport
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0006596Biological processpolyamine biosynthetic process
GO_0006595Biological processpolyamine metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008073Molecular functionornithine decarboxylase inhibitor activity

IV. Literature review

[source]
Gene nameOAZ2
Protein nameOrnithine decarboxylase antizyme 2
Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)
Synonyms
DescriptionFUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity . Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). .

AccessionsENST00000559912.2
J3QLV9
J3KRW5
J3KS80
O95190
ENST00000326005.10 [O95190-1]
ENST00000559753.1
ENST00000560258.6