NVL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032092Biological processpositive regulation of protein binding
GO_0042273Biological processribosomal large subunit biogenesis
GO_1904749Biological processregulation of protein localization to nucleolus
GO_0042254Biological processribosome biogenesis
GO_0006364Biological processrRNA processing
GO_0051973Biological processpositive regulation of telomerase activity
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0005634Cellular componentnucleus
GO_1990275Molecular functionpreribosome binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNVL
Protein nameNuclear VCP like
Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)
NVL protein
Nuclear VCP-like protein
SynonymsNVL2
DescriptionFUNCTION: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT . Involved in both early and late stages of the pre-rRNA processing pathways . Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus . Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity . .

AccessionsENST00000436927.5
A0A087WV72
ENST00000469968.5 [O15381-3]
E9PH71
ENST00000467882.5
ENST00000461546.2
E7EWK7
ENST00000340871.8 [O15381-4]
E9PGD8
A0JLP9
ENST00000281701.11 [O15381-1]
ENST00000492281.5
Q96PA2
ENST00000391875.6 [O15381-2]
ENST00000470989.5
ENST00000488718.5
ENST00000469075.5 [O15381-5]
ENST00000482491.5 [O15381-4]
C9J6P7
O15381
ENST00000481213.5
C9JP83
F8WF01