NPPB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPPB at tissue level.

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0003161Biological processcardiac conduction system development
GO_0007218Biological processneuropeptide signaling pathway
GO_0006182Biological processcGMP biosynthetic process
GO_0043114Biological processregulation of vascular permeability
GO_0008217Biological processregulation of blood pressure
GO_0097746Biological processblood vessel diameter maintenance
GO_0016525Biological processnegative regulation of angiogenesis
GO_0007168Biological processreceptor guanylyl cyclase signaling pathway
GO_0003085Biological processnegative regulation of systemic arterial blood pressure
GO_0007589Biological processbody fluid secretion
GO_0006457Biological processprotein folding
GO_0035815Biological processpositive regulation of renal sodium excretion
GO_0030308Biological processnegative regulation of cell growth
GO_0042311Biological processvasodilation
GO_0035810Biological processpositive regulation of urine volume
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0008613Molecular functiondiuretic hormone activity
GO_0051427Molecular functionhormone receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNPPB
Protein nameNatriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)]
Synonyms
DescriptionFUNCTION: [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis . May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses . Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion . Binds the clearance receptor NPR3 . .; FUNCTION: [NT-proBNP]: May affect cardio-renal homeostasis . Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 . .; FUNCTION: [BNP(3-32)]: May have a role in cardio-renal homeostasis . Able to promote the production of cGMP . .

AccessionsP16860
ENST00000376468.4