NPLOC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0032480Biological processnegative regulation of type I interferon production
GO_0007030Biological processGolgi organization
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0036501Cellular componentUFD1-NPL4 complex
GO_0042175Cellular componentnuclear outer membrane-endoplasmic reticulum membrane network
GO_0005654Cellular componentnucleoplasm
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0046872Molecular functionmetal ion binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameNPLOC4
Protein nameNPL4 homolog, ubiquitin recognition factor
Nuclear protein localization protein 4 homolog (Protein NPL4)
SynonymsNPL4
KIAA1499
DescriptionFUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI . .

AccessionsI3L4S2
ENST00000572824.1
K7EJN1
ENST00000570324.1
I3L3I1
ENST00000572760.5
A0A0D9SFI9
ENST00000625705.1
ENST00000571714.5
A0A994J7H4
ENST00000705719.1
Q8TAT6
I3L281
ENST00000573212.5
ENST00000574897.5
ENST00000573876.1
I3L4U9
ENST00000573519.5
ENST00000331134.11 [Q8TAT6-1]
I3L283
I3L0W3
ENST00000374747.9 [Q8TAT6-2]