NOTO report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOTO at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOTO at tissue level.

III. Associated gene sets

GO_0030182Biological processneuron differentiation
GO_0009880Biological processembryonic pattern specification
GO_0007417Biological processcentral nervous system development
GO_0030903Biological processnotochord development
GO_0044458Biological processmotile cilium assembly
GO_1902017Biological processregulation of cilium assembly
GO_0001947Biological processheart looping
GO_0009953Biological processdorsal/ventral pattern formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameNOTO
Protein nameHomeobox protein notochord
Synonyms
DescriptionFUNCTION: Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity). .

AccessionsENST00000398468.4
A8MTQ0