I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 19% ± 3% | |
| vein endothelial cell | 4 studies | 18% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 20% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 19% ± 3% | |
| vein endothelial cell | 4 studies | 18% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 20% ± 5% |
Insufficient scRNA-seq data for expression of NOS3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 2378.76 | 459 / 459 | 91% | 5.47 | 1013 / 1118 |
| intestine | 96% | 1028.64 | 932 / 966 | 92% | 6.74 | 485 / 527 |
| stomach | 92% | 780.17 | 330 / 359 | 96% | 8.81 | 275 / 286 |
| esophagus | 98% | 1111.67 | 1413 / 1445 | 90% | 8.38 | 164 / 183 |
| thymus | 100% | 1716.76 | 652 / 653 | 87% | 6.24 | 526 / 605 |
| prostate | 99% | 1406.82 | 242 / 245 | 84% | 4.86 | 424 / 502 |
| lung | 99% | 1900.08 | 575 / 578 | 83% | 8.35 | 957 / 1155 |
| adrenal gland | 99% | 1003.99 | 255 / 258 | 79% | 5.79 | 182 / 230 |
| bladder | 95% | 1734.62 | 20 / 21 | 75% | 4.59 | 380 / 504 |
| kidney | 100% | 1524.69 | 89 / 89 | 70% | 8.16 | 633 / 901 |
| uterus | 100% | 1808.88 | 170 / 170 | 57% | 2.81 | 263 / 459 |
| ovary | 72% | 496.09 | 130 / 180 | 83% | 4.86 | 358 / 430 |
| brain | 73% | 564.25 | 1933 / 2642 | 70% | 2.78 | 497 / 705 |
| skin | 69% | 488.28 | 1241 / 1809 | 75% | 5.18 | 354 / 472 |
| pancreas | 45% | 216.87 | 148 / 328 | 93% | 6.99 | 165 / 178 |
| liver | 54% | 362.27 | 122 / 226 | 53% | 2.46 | 214 / 406 |
| spleen | 100% | 10632.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2726.66 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 1902.64 | 857 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 85% | 1008.55 | 1139 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 2.23 | 26 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 2.06 | 16 / 29 |
| muscle | 54% | 324.36 | 437 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.61 | 16 / 80 |
| peripheral blood | 1% | 4.20 | 7 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045454 | Biological process | cell redox homeostasis |
| GO_0031663 | Biological process | lipopolysaccharide-mediated signaling pathway |
| GO_0001525 | Biological process | angiogenesis |
| GO_0003100 | Biological process | regulation of systemic arterial blood pressure by endothelin |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0009408 | Biological process | response to heat |
| GO_0010544 | Biological process | negative regulation of platelet activation |
| GO_0030324 | Biological process | lung development |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0002028 | Biological process | regulation of sodium ion transport |
| GO_0001542 | Biological process | ovulation from ovarian follicle |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0003057 | Biological process | regulation of the force of heart contraction by chemical signal |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0051926 | Biological process | negative regulation of calcium ion transport |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_0034405 | Biological process | response to fluid shear stress |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_0014740 | Biological process | negative regulation of muscle hyperplasia |
| GO_0097746 | Biological process | blood vessel diameter maintenance |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0006527 | Biological process | arginine catabolic process |
| GO_0009725 | Biological process | response to hormone |
| GO_0014806 | Biological process | smooth muscle hyperplasia |
| GO_0070168 | Biological process | negative regulation of biomineral tissue development |
| GO_0007005 | Biological process | mitochondrion organization |
| GO_0045776 | Biological process | negative regulation of blood pressure |
| GO_0043542 | Biological process | endothelial cell migration |
| GO_0006809 | Biological process | nitric oxide biosynthetic process |
| GO_0031284 | Biological process | positive regulation of guanylate cyclase activity |
| GO_0007263 | Biological process | nitric oxide mediated signal transduction |
| GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
| GO_0060412 | Biological process | ventricular septum morphogenesis |
| GO_0043267 | Biological process | negative regulation of potassium ion transport |
| GO_0031644 | Biological process | regulation of nervous system process |
| GO_1902042 | Biological process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0003184 | Biological process | pulmonary valve morphogenesis |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0019430 | Biological process | removal of superoxide radicals |
| GO_0042311 | Biological process | vasodilation |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005901 | Cellular component | caveola |
| GO_0005634 | Cellular component | nucleus |
| GO_0010181 | Molecular function | FMN binding |
| GO_0003785 | Molecular function | actin monomer binding |
| GO_0004517 | Molecular function | nitric-oxide synthase activity |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0034617 | Molecular function | tetrahydrobiopterin binding |
| GO_0046870 | Molecular function | cadmium ion binding |
| GO_0034618 | Molecular function | arginine binding |
| GO_0050661 | Molecular function | NADP binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOS3 |
| Protein name | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) NOS III Nitric oxide synthase (EC 1.14.13.39) nitric-oxide synthase (NADPH) (EC 1.14.13.39) |
| Synonyms | tcag7.753 |
| Description | FUNCTION: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway . NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. .; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions. . |
| Accessions | A0A090N8H8 ENST00000484524.5 [P29474-2] P29474 H7C4V4 E7ESA7 O14937 ENST00000475017.1 ENST00000467517.1 [P29474-3] ENST00000297494.8 [P29474-1] ENST00000461406.5 |
