NOS1AP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	10 studies	31% ± 11%	Explore
glutamatergic neuron	10 studies	48% ± 24%	Explore
GABAergic neuron	9 studies	47% ± 22%	Explore
endothelial cell	9 studies	28% ± 12%	Explore
astrocyte	8 studies	31% ± 13%	Explore
retinal cone cell	7 studies	42% ± 19%	Explore
interneuron	6 studies	47% ± 23%	Explore
retina horizontal cell	6 studies	24% ± 7%	Explore
microglial cell	5 studies	22% ± 4%	Explore
oligodendrocyte	5 studies	30% ± 11%	Explore
neuron	4 studies	24% ± 8%	Explore
club cell	4 studies	22% ± 7%	Explore
type I pneumocyte	4 studies	26% ± 6%	Explore
GABAergic interneuron	3 studies	39% ± 7%	Explore
Mueller cell	3 studies	21% ± 4%	Explore
hepatocyte	3 studies	64% ± 17%	Explore
ependymal cell	3 studies	36% ± 17%	Explore
granule cell	3 studies	27% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	36% ± 19%	Explore
kidney	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	1972.61	2583 / 2642	94%	4.94	661 / 705
stomach	95%	244.44	340 / 359	77%	2.02	219 / 286
intestine	91%	245.70	877 / 966	62%	1.28	325 / 527
esophagus	62%	129.16	901 / 1445	88%	3.33	161 / 183
breast	75%	288.31	346 / 459	70%	3.15	788 / 1118
prostate	84%	165.42	207 / 245	36%	0.62	182 / 502
liver	90%	369.93	203 / 226	27%	0.54	110 / 406
adrenal gland	56%	147.05	144 / 258	57%	2.77	132 / 230
lung	50%	72.02	287 / 578	51%	1.23	592 / 1155
kidney	91%	183.44	81 / 89	8%	0.16	73 / 901
bladder	67%	105.29	14 / 21	31%	0.61	157 / 504
ovary	21%	24.85	37 / 180	76%	2.00	325 / 430
uterus	56%	87.29	96 / 170	31%	0.58	141 / 459
skin	67%	157.33	1209 / 1809	13%	0.25	62 / 472
blood vessel	69%	142.85	918 / 1335	0%	0	0 / 0
heart	57%	95.94	491 / 861	0%	0	0 / 0
pancreas	22%	27.32	71 / 328	21%	0.37	37 / 178
adipose	39%	54.79	471 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	29%	0.47	13 / 45
thymus	3%	3.25	19 / 653	14%	0.21	83 / 605
peripheral blood	7%	11.72	67 / 929	0%	0	0 / 0
muscle	1%	1.62	11 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.03	1 / 80
spleen	1%	1.17	2 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901381	Biological process	positive regulation of potassium ion transmembrane transport
GO_0060307	Biological process	regulation of ventricular cardiac muscle cell membrane repolarization
GO_1902514	Biological process	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0003062	Biological process	regulation of heart rate by chemical signal
GO_2000170	Biological process	positive regulation of peptidyl-cysteine S-nitrosylation
GO_0045428	Biological process	regulation of nitric oxide biosynthetic process
GO_0050999	Biological process	regulation of nitric-oxide synthase activity
GO_0098974	Biological process	postsynaptic actin cytoskeleton organization
GO_0098901	Biological process	regulation of cardiac muscle cell action potential
GO_0006809	Biological process	nitric oxide biosynthetic process
GO_1901841	Biological process	regulation of high voltage-gated calcium channel activity
GO_1905026	Biological process	positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
GO_0098978	Cellular component	glutamatergic synapse
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0030018	Cellular component	Z disc
GO_0005739	Cellular component	mitochondrion
GO_0042383	Cellular component	sarcolemma
GO_0002102	Cellular component	podosome
GO_0030175	Cellular component	filopodium
GO_0030315	Cellular component	T-tubule
GO_0005829	Cellular component	cytosol
GO_0070161	Cellular component	anchoring junction
GO_0033017	Cellular component	sarcoplasmic reticulum membrane
GO_0031965	Cellular component	nuclear membrane
GO_0005901	Cellular component	caveola
GO_0005634	Cellular component	nucleus
GO_0050998	Molecular function	nitric-oxide synthase binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0030235	Molecular function	nitric-oxide synthase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NOS1AP
Protein name	Nitric oxide synthase 1 adaptor protein Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)
Synonyms	KIAA0464 CAPON
Description	FUNCTION: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation . .
Accessions	E9PSG0 ENST00000464284.1 ENST00000530878.5 [O75052-3] ENST00000493151.1 [O75052-2] ENST00000361897.10 [O75052-1] E9PIP8 O75052 ENST00000430120.3

NOS1AP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review