NKRF report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NKRF at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKRF at tissue level.

III. Associated gene sets

GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0001671Molecular functionATPase activator activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNKRF
Protein nameTruncated NF-kappaB repressing factor
NF-kappaB repressing factor
NFKB repressing factor
NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4)
SynonymsNRF
hCG_23185
ITBA4
DescriptionFUNCTION: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 . Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity . Also involved in the regulation of IL-8 transcription . May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes . .

AccessionsQ6NUN2
ENST00000688521.1
A2I830
ENST00000542113.3 [O15226-2]
A1Z1A7
A2I827
A2I831
A2I832
A3F769
ENST00000304449.8 [O15226-1]
A2I829
A2I828
A0A8I5KX72
O15226