Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 9 studies | 46% ± 22% | |
| retinal cone cell | 7 studies | 53% ± 27% | |
| enteroendocrine cell | 6 studies | 55% ± 19% | |
| pancreatic A cell | 4 studies | 56% ± 21% | |
| type B pancreatic cell | 4 studies | 54% ± 22% | |
| pancreatic D cell | 3 studies | 57% ± 24% | |
| retinal bipolar neuron | 3 studies | 32% ± 10% | |
| ON-bipolar cell | 3 studies | 25% ± 9% | |
| glycinergic amacrine cell | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 98% | 238.95 | 320 / 328 | 69% | 13.10 | 123 / 178 |
| brain | 62% | 3404.52 | 1649 / 2642 | 82% | 6.57 | 581 / 705 |
| stomach | 69% | 103.98 | 248 / 359 | 10% | 1.30 | 29 / 286 |
| intestine | 34% | 38.81 | 333 / 966 | 12% | 1.92 | 62 / 527 |
| adrenal gland | 0% | 12.52 | 1 / 258 | 10% | 1.10 | 22 / 230 |
| eye | 0% | 0 | 0 / 0 | 8% | 2.33 | 6 / 80 |
| esophagus | 1% | 0.57 | 8 / 1445 | 7% | 0.62 | 12 / 183 |
| lung | 0% | 0.07 | 1 / 578 | 6% | 1.81 | 67 / 1155 |
| uterus | 0% | 0 | 0 / 170 | 4% | 0.37 | 18 / 459 |
| bladder | 0% | 0 | 0 / 21 | 3% | 1.04 | 15 / 504 |
| prostate | 2% | 0.85 | 4 / 245 | 1% | 0.03 | 5 / 502 |
| ovary | 2% | 4.56 | 3 / 180 | 1% | 0.02 | 4 / 430 |
| liver | 1% | 0.73 | 2 / 226 | 1% | 0.09 | 5 / 406 |
| breast | 0% | 0 | 0 / 459 | 1% | 0.41 | 13 / 1118 |
| skin | 0% | 0.22 | 3 / 1809 | 0% | 0.02 | 2 / 472 |
| peripheral blood | 1% | 0.39 | 5 / 929 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.03 | 4 / 901 |
| spleen | 0% | 0.16 | 1 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.23 | 3 / 803 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.07 | 2 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0 | 0 / 653 | 0% | 0.00 | 1 / 605 |
| blood vessel | 0% | 0.23 | 2 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.15 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_2000679 | Biological process | positive regulation of transcription regulatory region DNA binding |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0061564 | Biological process | axon development |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0046426 | Biological process | negative regulation of receptor signaling pathway via JAK-STAT |
| GO_0009749 | Biological process | response to glucose |
| GO_0048562 | Biological process | embryonic organ morphogenesis |
| GO_0021542 | Biological process | dentate gyrus development |
| GO_0035883 | Biological process | enteroendocrine cell differentiation |
| GO_2000675 | Biological process | negative regulation of type B pancreatic cell apoptotic process |
| GO_0048839 | Biological process | inner ear development |
| GO_0003329 | Biological process | pancreatic PP cell fate commitment |
| GO_0060730 | Biological process | regulation of intestinal epithelial structure maintenance |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0022008 | Biological process | neurogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0003326 | Biological process | pancreatic A cell fate commitment |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0006913 | Biological process | nucleocytoplasmic transport |
| GO_0021549 | Biological process | cerebellum development |
| GO_0030073 | Biological process | insulin secretion |
| GO_0031018 | Biological process | endocrine pancreas development |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0007423 | Biological process | sensory organ development |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0035881 | Biological process | amacrine cell differentiation |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0070888 | Molecular function | E-box binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NEUROD1 |
| Protein name | Neurogenic differentiation factor 1 Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3) Neurogenic differentiation 1 isoform 2 |
| Synonyms | BHLHA3 NEUROD |
| Description | FUNCTION: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). . |
| Accessions | E0X9P1 A0A0S2Z4S1 ENST00000295108.4 A0A0S2Z493 ENST00000684079.1 ENST00000683430.1 Q13562 |
