NEURL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007288Biological processsperm axoneme assembly
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048170Biological processpositive regulation of long-term neuronal synaptic plasticity
GO_0007519Biological processskeletal muscle tissue development
GO_0007219Biological processNotch signaling pathway
GO_0006417Biological processregulation of translation
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0071230Biological processcellular response to amino acid stimulus
GO_0090129Biological processpositive regulation of synapse maturation
GO_0007595Biological processlactation
GO_0006513Biological processprotein monoubiquitination
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0007399Biological processnervous system development
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043204Cellular componentperikaryon
GO_0014069Cellular componentpostsynaptic density
GO_0097440Cellular componentapical dendrite
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0045183Molecular functiontranslation factor activity, non-nucleic acid binding
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEURL1
Protein nameE3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1)
Neuralized E3 ubiquitin protein ligase 1
SynonymsRNF67
NEURL1A
NEURL
DescriptionFUNCTION: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. .

AccessionsX6RLA8
O76050
ENST00000369780.9 [O76050-1]
X6RBV8
ENST00000455386.1
ENST00000437579.1