Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 24% ± 7% | |
ciliated cell | 11 studies | 26% ± 10% | |
fibroblast | 7 studies | 31% ± 23% | |
epithelial cell | 7 studies | 34% ± 13% | |
macrophage | 7 studies | 29% ± 20% | |
pericyte | 6 studies | 28% ± 20% | |
basal cell | 6 studies | 26% ± 7% | |
oligodendrocyte | 6 studies | 23% ± 7% | |
regulatory T cell | 5 studies | 18% ± 3% | |
classical monocyte | 4 studies | 20% ± 3% | |
natural killer cell | 4 studies | 19% ± 3% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
astrocyte | 4 studies | 26% ± 5% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 8% | |
goblet cell | 4 studies | 23% ± 2% | |
squamous epithelial cell | 3 studies | 39% ± 24% | |
conventional dendritic cell | 3 studies | 36% ± 27% | |
microglial cell | 3 studies | 20% ± 3% | |
club cell | 3 studies | 20% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 21% ± 4% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 3% | |
lymphocyte | 3 studies | 16% ± 1% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 16% ± 1% | |
dendritic cell | 3 studies | 30% ± 10% | |
endothelial cell of vascular tree | 3 studies | 33% ± 24% | |
secretory cell | 3 studies | 18% ± 1% | |
GABAergic neuron | 3 studies | 39% ± 6% | |
glutamatergic neuron | 3 studies | 49% ± 8% | |
abnormal cell | 3 studies | 24% ± 10% | |
enteroendocrine cell | 3 studies | 22% ± 5% | |
brush cell | 3 studies | 26% ± 6% | |
interneuron | 3 studies | 33% ± 15% | |
neuron | 3 studies | 29% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 8016.56 | 1445 / 1445 | 100% | 58.02 | 183 / 183 |
prostate | 100% | 9128.52 | 245 / 245 | 100% | 95.62 | 502 / 502 |
brain | 100% | 7153.89 | 2641 / 2642 | 100% | 93.48 | 705 / 705 |
bladder | 100% | 9351.62 | 21 / 21 | 100% | 54.24 | 503 / 504 |
lung | 100% | 7283.49 | 577 / 578 | 100% | 59.71 | 1154 / 1155 |
stomach | 100% | 6688.55 | 359 / 359 | 100% | 63.06 | 285 / 286 |
breast | 100% | 9258.67 | 459 / 459 | 100% | 81.57 | 1113 / 1118 |
thymus | 100% | 9145.99 | 653 / 653 | 100% | 91.53 | 602 / 605 |
uterus | 100% | 9016.20 | 170 / 170 | 99% | 46.83 | 456 / 459 |
intestine | 100% | 9239.41 | 966 / 966 | 99% | 62.89 | 523 / 527 |
kidney | 100% | 6929.84 | 89 / 89 | 99% | 79.67 | 893 / 901 |
skin | 100% | 9314.92 | 1808 / 1809 | 98% | 74.97 | 464 / 472 |
pancreas | 99% | 3822.46 | 324 / 328 | 99% | 67.11 | 177 / 178 |
liver | 99% | 5001.63 | 223 / 226 | 99% | 53.15 | 400 / 406 |
adrenal gland | 100% | 9878.66 | 258 / 258 | 97% | 55.32 | 223 / 230 |
ovary | 100% | 9733.41 | 180 / 180 | 95% | 30.42 | 408 / 430 |
adipose | 100% | 9068.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 11184.32 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 40.28 | 29 / 29 |
muscle | 100% | 13828.61 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 7410.65 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 50.58 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.70 | 1 / 1 |
heart | 97% | 6600.29 | 832 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 60.23 | 77 / 80 |
peripheral blood | 96% | 4991.76 | 893 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016236 | Biological process | macroautophagy |
GO_0030500 | Biological process | regulation of bone mineralization |
GO_0032872 | Biological process | regulation of stress-activated MAPK cascade |
GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0043235 | Cellular component | receptor complex |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005764 | Cellular component | lysosome |
GO_0005758 | Cellular component | mitochondrial intermembrane space |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016604 | Cellular component | nuclear body |
GO_0005829 | Cellular component | cytosol |
GO_0005770 | Cellular component | late endosome |
GO_0000407 | Cellular component | phagophore assembly site |
GO_0005776 | Cellular component | autophagosome |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0031430 | Cellular component | M band |
GO_0051019 | Molecular function | mitogen-activated protein kinase binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | NBR1 |
Protein name | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 autophagy cargo receptor (cDNA FLJ55359, highly similar to Next to BRCA1 gene 1 protein) Neighbor of BRCA1 gene 1 NBR1 autophagy cargo receptor Alternative protein NBR1 |
Synonyms | KIAA0049 M17S2 MIG19 1A13B |
Description | FUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis . Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates . Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation . In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). . |
Accessions | Q14596 Q3LRK1 ENST00000542611.5 A0A0C4DGP6 ENST00000589872.1 [Q14596-2] B7Z5R6 ENST00000341165.10 [Q14596-1] Q3LRJ8 Q3LRI0 L8E9A2 Q3LRI9 Q3LRJ5 ENST00000590996.6 [Q14596-1] Q3LRI6 ENST00000586650.5 |