NBR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016236Biological processmacroautophagy
GO_0030500Biological processregulation of bone mineralization
GO_0032872Biological processregulation of stress-activated MAPK cascade
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0005778Cellular componentperoxisomal membrane
GO_0043235Cellular componentreceptor complex
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005764Cellular componentlysosome
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031430Cellular componentM band
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameNBR1
Protein nameNext to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)
NBR1 autophagy cargo receptor (cDNA FLJ55359, highly similar to Next to BRCA1 gene 1 protein)
Neighbor of BRCA1 gene 1
NBR1 autophagy cargo receptor
Alternative protein NBR1
SynonymsKIAA0049
M17S2
MIG19
1A13B
DescriptionFUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis . Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates . Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation . In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). .

AccessionsQ14596
Q3LRK1
ENST00000542611.5
A0A0C4DGP6
ENST00000589872.1 [Q14596-2]
B7Z5R6
ENST00000341165.10 [Q14596-1]
Q3LRJ8
Q3LRI0
L8E9A2
Q3LRI9
Q3LRJ5
ENST00000590996.6 [Q14596-1]
Q3LRI6
ENST00000586650.5