Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 26% ± 9% | |
macrophage | 11 studies | 28% ± 10% | |
type I pneumocyte | 9 studies | 35% ± 11% | |
monocyte | 8 studies | 22% ± 6% | |
glutamatergic neuron | 7 studies | 38% ± 24% | |
epithelial cell | 7 studies | 31% ± 16% | |
GABAergic neuron | 7 studies | 33% ± 20% | |
oligodendrocyte | 7 studies | 24% ± 7% | |
microglial cell | 6 studies | 26% ± 7% | |
astrocyte | 6 studies | 27% ± 10% | |
natural killer cell | 5 studies | 20% ± 4% | |
classical monocyte | 5 studies | 20% ± 4% | |
myeloid cell | 5 studies | 25% ± 2% | |
fibroblast | 5 studies | 18% ± 4% | |
T cell | 4 studies | 21% ± 2% | |
squamous epithelial cell | 4 studies | 39% ± 21% | |
non-classical monocyte | 4 studies | 24% ± 9% | |
neuron | 4 studies | 24% ± 11% | |
basal cell | 4 studies | 29% ± 10% | |
club cell | 4 studies | 22% ± 6% | |
lymphocyte | 4 studies | 27% ± 8% | |
oligodendrocyte precursor cell | 4 studies | 34% ± 10% | |
dendritic cell | 4 studies | 21% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 19% ± 3% | |
interneuron | 4 studies | 39% ± 23% | |
leukocyte | 3 studies | 26% ± 7% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 22% ± 3% | |
CD4-positive, alpha-beta T cell | 3 studies | 21% ± 4% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 6% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 25% ± 6% | |
granule cell | 3 studies | 18% ± 2% | |
adipocyte | 3 studies | 22% ± 4% | |
ciliated cell | 3 studies | 28% ± 5% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 20% ± 3% | |
gamma-delta T cell | 3 studies | 22% ± 3% | |
mature NK T cell | 3 studies | 18% ± 1% | |
regulatory T cell | 3 studies | 19% ± 4% | |
alveolar macrophage | 3 studies | 33% ± 13% | |
goblet cell | 3 studies | 37% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 3135.24 | 21 / 21 | 100% | 24.69 | 504 / 504 |
breast | 100% | 3754.37 | 459 / 459 | 100% | 29.49 | 1118 / 1118 |
esophagus | 100% | 4247.82 | 1445 / 1445 | 100% | 45.03 | 183 / 183 |
intestine | 100% | 3313.14 | 966 / 966 | 100% | 22.09 | 527 / 527 |
lung | 100% | 4797.10 | 578 / 578 | 100% | 29.94 | 1155 / 1155 |
ovary | 100% | 3206.22 | 180 / 180 | 100% | 19.80 | 430 / 430 |
prostate | 100% | 3451.21 | 245 / 245 | 100% | 25.47 | 502 / 502 |
skin | 100% | 5527.30 | 1809 / 1809 | 100% | 25.04 | 472 / 472 |
stomach | 100% | 2698.98 | 359 / 359 | 100% | 22.28 | 286 / 286 |
uterus | 100% | 3473.01 | 170 / 170 | 100% | 30.54 | 459 / 459 |
thymus | 100% | 3295.15 | 652 / 653 | 100% | 26.33 | 605 / 605 |
kidney | 100% | 2404.36 | 89 / 89 | 100% | 19.77 | 899 / 901 |
adrenal gland | 100% | 2351.40 | 258 / 258 | 99% | 19.52 | 228 / 230 |
brain | 99% | 2315.71 | 2611 / 2642 | 100% | 20.93 | 705 / 705 |
pancreas | 98% | 1514.64 | 320 / 328 | 99% | 24.90 | 177 / 178 |
liver | 100% | 1398.76 | 226 / 226 | 96% | 9.67 | 390 / 406 |
adipose | 100% | 3581.07 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 21.16 | 29 / 29 |
spleen | 100% | 4118.78 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 37.73 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.62 | 1 / 1 |
blood vessel | 100% | 2633.57 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2284.00 | 801 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 6323.19 | 922 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 20.55 | 79 / 80 |
heart | 98% | 1653.01 | 840 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045088 | Biological process | regulation of innate immune response |
GO_0045071 | Biological process | negative regulation of viral genome replication |
GO_0031397 | Biological process | negative regulation of protein ubiquitination |
GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0034644 | Biological process | cellular response to UV |
GO_0045087 | Biological process | innate immune response |
GO_0001818 | Biological process | negative regulation of cytokine production |
GO_0016605 | Cellular component | PML body |
GO_0005730 | Cellular component | nucleolus |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0004540 | Molecular function | RNA nuclease activity |
GO_0003729 | Molecular function | mRNA binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | N4BP1 |
Protein name | NEDD4 binding protein 1 NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) |
Synonyms | KIAA0615 |
Description | FUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity . Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). . |
Accessions | O75113 ENST00000262384.4 I3L3R7 ENST00000564710.1 |