N4BP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045088Biological processregulation of innate immune response
GO_0045071Biological processnegative regulation of viral genome replication
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0034644Biological processcellular response to UV
GO_0045087Biological processinnate immune response
GO_0001818Biological processnegative regulation of cytokine production
GO_0016605Cellular componentPML body
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity
GO_0003729Molecular functionmRNA binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameN4BP1
Protein nameNEDD4 binding protein 1
NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-)
SynonymsKIAA0615
DescriptionFUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity . Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). .

AccessionsO75113
ENST00000262384.4
I3L3R7
ENST00000564710.1