MYSM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903706Biological processregulation of hemopoiesis
GO_0002376Biological processimmune system process
GO_0006338Biological processchromatin remodeling
GO_0030334Biological processregulation of cell migration
GO_0043473Biological processpigmentation
GO_0006508Biological processproteolysis
GO_0051797Biological processregulation of hair follicle development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140492Molecular functionmetal-dependent deubiquitinase activity
GO_0003677Molecular functionDNA binding
GO_0140950Molecular functionhistone H2A deubiquitinase activity
GO_0042393Molecular functionhistone binding
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYSM1
Protein nameMyb like, SWIRM and MPN domains 1
Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)
Myb-like, SWIRM and MPN domain-containing protein 1
SynonymsKIAA1915
DescriptionFUNCTION: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response . Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity . Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains . In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors . Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome . .

AccessionsA0A590UJT8
ENST00000697255.1
ENST00000659108.1
ENST00000665648.1
Q5VVJ2
ENST00000697253.1
A0A8V8TMF1
ENST00000697254.1
A0A590UJW2
A0A8V8TKW8
ENST00000472487.6 [Q5VVJ2-1]
A0A590UK32
A0A590UJD8
ENST00000659812.2
ENST00000655340.1