Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 25% ± 9% | |
oligodendrocyte | 12 studies | 27% ± 10% | |
glutamatergic neuron | 9 studies | 40% ± 26% | |
oligodendrocyte precursor cell | 9 studies | 28% ± 13% | |
astrocyte | 8 studies | 27% ± 12% | |
GABAergic neuron | 7 studies | 34% ± 19% | |
endothelial cell of lymphatic vessel | 6 studies | 25% ± 7% | |
microglial cell | 6 studies | 24% ± 6% | |
interneuron | 6 studies | 31% ± 22% | |
epithelial cell | 5 studies | 34% ± 12% | |
fibroblast | 5 studies | 20% ± 5% | |
macrophage | 5 studies | 27% ± 6% | |
adipocyte | 4 studies | 24% ± 8% | |
cardiac muscle cell | 4 studies | 20% ± 2% | |
lymphocyte | 3 studies | 23% ± 2% | |
myeloid cell | 3 studies | 17% ± 2% | |
basal cell | 3 studies | 25% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3650.47 | 1444 / 1445 | 100% | 12.97 | 183 / 183 |
lung | 100% | 4276.56 | 577 / 578 | 98% | 8.32 | 1134 / 1155 |
breast | 100% | 5723.22 | 459 / 459 | 98% | 11.39 | 1091 / 1118 |
prostate | 100% | 4025.78 | 245 / 245 | 97% | 9.95 | 489 / 502 |
intestine | 100% | 4727.22 | 966 / 966 | 96% | 6.96 | 505 / 527 |
stomach | 100% | 3260.94 | 359 / 359 | 95% | 8.08 | 272 / 286 |
bladder | 100% | 3871.86 | 21 / 21 | 95% | 7.44 | 479 / 504 |
ovary | 100% | 5116.46 | 180 / 180 | 94% | 5.43 | 406 / 430 |
thymus | 100% | 5147.33 | 653 / 653 | 94% | 6.88 | 569 / 605 |
pancreas | 100% | 2772.66 | 328 / 328 | 93% | 6.48 | 166 / 178 |
uterus | 100% | 5224.15 | 170 / 170 | 93% | 7.35 | 426 / 459 |
kidney | 100% | 2457.29 | 89 / 89 | 92% | 7.04 | 825 / 901 |
brain | 94% | 2110.04 | 2481 / 2642 | 97% | 6.41 | 684 / 705 |
skin | 100% | 4399.18 | 1809 / 1809 | 87% | 7.68 | 411 / 472 |
adrenal gland | 100% | 2949.61 | 258 / 258 | 79% | 3.22 | 182 / 230 |
liver | 99% | 1576.50 | 224 / 226 | 59% | 2.67 | 238 / 406 |
adipose | 100% | 4511.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 4374.73 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3476.72 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2403.38 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 2525.96 | 830 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 6.61 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 72% | 5.12 | 21 / 29 |
peripheral blood | 61% | 1753.83 | 568 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 51% | 3.54 | 41 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1903706 | Biological process | regulation of hemopoiesis |
GO_0002376 | Biological process | immune system process |
GO_0006338 | Biological process | chromatin remodeling |
GO_0030334 | Biological process | regulation of cell migration |
GO_0043473 | Biological process | pigmentation |
GO_0006508 | Biological process | proteolysis |
GO_0051797 | Biological process | regulation of hair follicle development |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005730 | Cellular component | nucleolus |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0140492 | Molecular function | metal-dependent deubiquitinase activity |
GO_0003677 | Molecular function | DNA binding |
GO_0140950 | Molecular function | histone H2A deubiquitinase activity |
GO_0042393 | Molecular function | histone binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MYSM1 |
Protein name | Myb like, SWIRM and MPN domains 1 Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) Myb-like, SWIRM and MPN domain-containing protein 1 |
Synonyms | KIAA1915 |
Description | FUNCTION: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response . Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity . Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains . In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors . Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome . . |
Accessions | A0A590UJT8 ENST00000697255.1 ENST00000659108.1 ENST00000665648.1 Q5VVJ2 ENST00000697253.1 A0A8V8TMF1 ENST00000697254.1 A0A590UJW2 A0A8V8TKW8 ENST00000472487.6 [Q5VVJ2-1] A0A590UK32 A0A590UJD8 ENST00000659812.2 ENST00000655340.1 |