MYOG report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MYOG at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYOG at tissue level.

III. Associated gene sets

GO_0071285Biological processcellular response to lithium ion
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007519Biological processskeletal muscle tissue development
GO_0014891Biological processstriated muscle atrophy
GO_0048741Biological processskeletal muscle fiber development
GO_0014894Biological processresponse to denervation involved in regulation of muscle adaptation
GO_0071392Biological processcellular response to estradiol stimulus
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0014737Biological processpositive regulation of muscle atrophy
GO_0014878Biological processresponse to electrical stimulus involved in regulation of muscle adaptation
GO_0071363Biological processcellular response to growth factor stimulus
GO_0042693Biological processmuscle cell fate commitment
GO_0010831Biological processpositive regulation of myotube differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0014842Biological processregulation of skeletal muscle satellite cell proliferation
GO_1901739Biological processregulation of myoblast fusion
GO_0001503Biological processossification
GO_0035914Biological processskeletal muscle cell differentiation
GO_0014873Biological processresponse to muscle activity involved in regulation of muscle adaptation
GO_0048743Biological processpositive regulation of skeletal muscle fiber development
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0031490Molecular functionchromatin DNA binding
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYOG
Protein nameMyogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4)
Alternative protein MYOG
SynonymsMYF4
BHLHC3
DescriptionFUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). .

AccessionsENST00000241651.5
L8E8X4
P15173