MYOD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MYOD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYOD1 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0014904Biological processmyotube cell development
GO_0007519Biological processskeletal muscle tissue development
GO_0007518Biological processmyoblast fate determination
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048741Biological processskeletal muscle fiber development
GO_1905382Biological processpositive regulation of snRNA transcription by RNA polymerase II
GO_0051149Biological processpositive regulation of muscle cell differentiation
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0071392Biological processcellular response to estradiol stimulus
GO_0014908Biological processmyotube differentiation involved in skeletal muscle regeneration
GO_0009267Biological processcellular response to starvation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0042693Biological processmuscle cell fate commitment
GO_1901741Biological processpositive regulation of myoblast fusion
GO_0071356Biological processcellular response to tumor necrosis factor
GO_2000818Biological processnegative regulation of myoblast proliferation
GO_0043415Biological processpositive regulation of skeletal muscle tissue regeneration
GO_0043503Biological processskeletal muscle fiber adaptation
GO_0007517Biological processmuscle organ development
GO_0071453Biological processcellular response to oxygen levels
GO_0043484Biological processregulation of RNA splicing
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0007520Biological processmyoblast fusion
GO_0006468Biological processprotein phosphorylation
GO_0035914Biological processskeletal muscle cell differentiation
GO_0048743Biological processpositive regulation of skeletal muscle fiber development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000791Cellular componenteuchromatin
GO_0030016Cellular componentmyofibril
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0031490Molecular functionchromatin DNA binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYOD1
Protein nameMyoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3)
SynonymsBHLHC1
MYF3
MYOD
DescriptionFUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). .

AccessionsENST00000250003.4
P15172