MTF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0048863Biological processstem cell differentiation
GO_0040029Biological processepigenetic regulation of gene expression
GO_0019827Biological processstem cell population maintenance
GO_0007379Biological processsegment specification
GO_0035098Cellular componentESC/E(Z) complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameMTF2
Protein nameMetal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)
Metal response element binding transcription factor 2, isoform CRA_c (cDNA FLJ50106, highly similar to Metal-response element-binding transcriptionfactor 2)
SynonymsPCL2
hCG_31944
DescriptionFUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity . Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). .

AccessionsQ9Y483
ENST00000370303.4 [Q9Y483-4]
ENST00000370298.9 [Q9Y483-1]
ENST00000540243.5 [Q9Y483-3]
ENST00000545708.5 [Q9Y483-3]
B4DZG1