Insufficient scRNA-seq data for expression of MSTN at single-cell level.
Insufficient scRNA-seq data for expression of MSTN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 98% | 75.61 | 2598 / 2642 | 93% | 26.15 | 654 / 705 |
adrenal gland | 99% | 128.84 | 255 / 258 | 36% | 0.83 | 83 / 230 |
kidney | 99% | 64.97 | 88 / 89 | 26% | 0.53 | 238 / 901 |
prostate | 98% | 53.56 | 239 / 245 | 11% | 0.20 | 55 / 502 |
thymus | 97% | 60.50 | 636 / 653 | 10% | 0.19 | 63 / 605 |
uterus | 96% | 80.42 | 163 / 170 | 11% | 2.14 | 50 / 459 |
breast | 96% | 55.75 | 440 / 459 | 8% | 0.18 | 94 / 1118 |
skin | 94% | 101.27 | 1694 / 1809 | 10% | 0.43 | 47 / 472 |
ovary | 97% | 58.11 | 175 / 180 | 3% | 0.33 | 11 / 430 |
adipose | 96% | 62.07 | 1156 / 1204 | 0% | 0 | 0 / 0 |
intestine | 92% | 61.55 | 892 / 966 | 2% | 0.03 | 12 / 527 |
blood vessel | 94% | 61.58 | 1260 / 1335 | 0% | 0 | 0 / 0 |
bladder | 90% | 28.43 | 19 / 21 | 4% | 0.09 | 19 / 504 |
muscle | 94% | 216.64 | 755 / 803 | 0% | 0 | 0 / 0 |
lung | 88% | 34.06 | 511 / 578 | 5% | 1.88 | 55 / 1155 |
spleen | 88% | 28.44 | 212 / 241 | 0% | 0 | 0 / 0 |
esophagus | 84% | 37.27 | 1211 / 1445 | 4% | 0.10 | 7 / 183 |
stomach | 70% | 23.04 | 253 / 359 | 3% | 0.77 | 9 / 286 |
pancreas | 67% | 16.42 | 219 / 328 | 4% | 0.08 | 7 / 178 |
heart | 64% | 20.07 | 547 / 861 | 0% | 0 | 0 / 0 |
liver | 44% | 9.80 | 99 / 226 | 2% | 0.04 | 7 / 406 |
peripheral blood | 3% | 0.59 | 27 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 0.04 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0014732 | Biological process | skeletal muscle atrophy |
GO_0033574 | Biological process | response to testosterone |
GO_0071549 | Biological process | cellular response to dexamethasone stimulus |
GO_0014816 | Biological process | skeletal muscle satellite cell differentiation |
GO_0043627 | Biological process | response to estrogen |
GO_0046716 | Biological process | muscle cell cellular homeostasis |
GO_1902723 | Biological process | negative regulation of skeletal muscle satellite cell proliferation |
GO_0051602 | Biological process | response to electrical stimulus |
GO_0045662 | Biological process | negative regulation of myoblast differentiation |
GO_0048632 | Biological process | negative regulation of skeletal muscle tissue growth |
GO_0071456 | Biological process | cellular response to hypoxia |
GO_0010592 | Biological process | positive regulation of lamellipodium assembly |
GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
GO_0045471 | Biological process | response to ethanol |
GO_0014850 | Biological process | response to muscle activity |
GO_0010759 | Biological process | positive regulation of macrophage chemotaxis |
GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0022602 | Biological process | ovulation cycle process |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_2000818 | Biological process | negative regulation of myoblast proliferation |
GO_0009629 | Biological process | response to gravity |
GO_0007517 | Biological process | muscle organ development |
GO_1902725 | Biological process | negative regulation of satellite cell differentiation |
GO_0014741 | Biological process | negative regulation of muscle hypertrophy |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_0014839 | Biological process | myoblast migration involved in skeletal muscle regeneration |
GO_0005615 | Cellular component | extracellular space |
GO_0008201 | Molecular function | heparin binding |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0008083 | Molecular function | growth factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0005125 | Molecular function | cytokine activity |
Gene name | MSTN |
Protein name | Growth/differentiation factor 8 (GDF-8) (Myostatin) |
Synonyms | GDF8 |
Description | FUNCTION: Acts specifically as a negative regulator of skeletal muscle growth. . |
Accessions | O14793 ENST00000260950.5 |