MSTN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MSTN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MSTN at tissue level.

III. Associated gene sets

GO_0014732Biological processskeletal muscle atrophy
GO_0033574Biological processresponse to testosterone
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0014816Biological processskeletal muscle satellite cell differentiation
GO_0043627Biological processresponse to estrogen
GO_0046716Biological processmuscle cell cellular homeostasis
GO_1902723Biological processnegative regulation of skeletal muscle satellite cell proliferation
GO_0051602Biological processresponse to electrical stimulus
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0048632Biological processnegative regulation of skeletal muscle tissue growth
GO_0071456Biological processcellular response to hypoxia
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0045471Biological processresponse to ethanol
GO_0014850Biological processresponse to muscle activity
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0022602Biological processovulation cycle process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000818Biological processnegative regulation of myoblast proliferation
GO_0009629Biological processresponse to gravity
GO_0007517Biological processmuscle organ development
GO_1902725Biological processnegative regulation of satellite cell differentiation
GO_0014741Biological processnegative regulation of muscle hypertrophy
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0014839Biological processmyoblast migration involved in skeletal muscle regeneration
GO_0005615Cellular componentextracellular space
GO_0008201Molecular functionheparin binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0008083Molecular functiongrowth factor activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameMSTN
Protein nameGrowth/differentiation factor 8 (GDF-8) (Myostatin)
SynonymsGDF8
DescriptionFUNCTION: Acts specifically as a negative regulator of skeletal muscle growth. .

AccessionsO14793
ENST00000260950.5