MSH3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0016447Biological processsomatic recombination of immunoglobulin gene segments
GO_0051096Biological processpositive regulation of helicase activity
GO_0006298Biological processmismatch repair
GO_0006312Biological processmitotic recombination
GO_0043570Biological processmaintenance of DNA repeat elements
GO_0045910Biological processnegative regulation of DNA recombination
GO_0016020Cellular componentmembrane
GO_0032302Cellular componentMutSbeta complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0032142Molecular functionsingle guanine insertion binding
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0032181Molecular functiondinucleotide repeat insertion binding
GO_0032137Molecular functionguanine/thymine mispair binding
GO_0030983Molecular functionmismatched DNA binding
GO_0032139Molecular functiondinucleotide insertion or deletion binding
GO_0005524Molecular functionATP binding
GO_0032357Molecular functionoxidized purine DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMSH3
Protein nameDNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)
MutS homolog 3
SynonymsDUC1
DUG
DescriptionFUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

AccessionsENST00000658259.1
ENST00000667069.1
P20585
ENST00000265081.7
ENST00000659302.1
A0A590UJN8
A0A590UJW0
A0A590UK39
ENST00000670357.1
A0A590UKC9