Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 16 studies | 26% ± 7% | |
endothelial cell | 12 studies | 26% ± 11% | |
astrocyte | 11 studies | 33% ± 17% | |
glutamatergic neuron | 10 studies | 40% ± 26% | |
oligodendrocyte | 10 studies | 28% ± 12% | |
oligodendrocyte precursor cell | 9 studies | 27% ± 12% | |
GABAergic neuron | 8 studies | 41% ± 24% | |
microglial cell | 8 studies | 26% ± 8% | |
adipocyte | 8 studies | 35% ± 10% | |
interneuron | 6 studies | 40% ± 25% | |
epithelial cell | 6 studies | 29% ± 13% | |
fibroblast | 6 studies | 23% ± 7% | |
neuron | 5 studies | 35% ± 17% | |
T cell | 5 studies | 18% ± 2% | |
macrophage | 5 studies | 28% ± 8% | |
type II pneumocyte | 5 studies | 19% ± 5% | |
basal cell | 5 studies | 26% ± 15% | |
type I pneumocyte | 4 studies | 21% ± 5% | |
gamma-delta T cell | 4 studies | 24% ± 6% | |
GABAergic interneuron | 3 studies | 25% ± 1% | |
retinal rod cell | 3 studies | 18% ± 1% | |
myeloid cell | 3 studies | 17% ± 3% | |
hepatocyte | 3 studies | 46% ± 11% | |
dendritic cell | 3 studies | 18% ± 2% | |
alveolar macrophage | 3 studies | 23% ± 7% | |
endothelial cell of lymphatic vessel | 3 studies | 23% ± 3% | |
monocyte | 3 studies | 23% ± 2% | |
lymphocyte | 3 studies | 24% ± 10% | |
transit amplifying cell | 3 studies | 34% ± 24% | |
mucus secreting cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 602.83 | 1445 / 1445 | 100% | 13.53 | 183 / 183 |
prostate | 100% | 667.19 | 245 / 245 | 100% | 15.38 | 502 / 502 |
thymus | 100% | 859.39 | 653 / 653 | 100% | 14.74 | 604 / 605 |
brain | 100% | 574.92 | 2636 / 2642 | 100% | 11.20 | 704 / 705 |
uterus | 100% | 677.86 | 170 / 170 | 100% | 12.71 | 457 / 459 |
breast | 100% | 857.95 | 459 / 459 | 100% | 18.51 | 1113 / 1118 |
bladder | 100% | 721.00 | 21 / 21 | 99% | 11.56 | 501 / 504 |
lung | 100% | 620.29 | 576 / 578 | 100% | 11.14 | 1150 / 1155 |
liver | 100% | 535.95 | 226 / 226 | 99% | 9.04 | 400 / 406 |
pancreas | 99% | 522.85 | 326 / 328 | 99% | 10.53 | 176 / 178 |
stomach | 100% | 490.04 | 359 / 359 | 98% | 12.03 | 281 / 286 |
kidney | 100% | 838.34 | 89 / 89 | 98% | 13.23 | 881 / 901 |
intestine | 100% | 669.59 | 966 / 966 | 97% | 12.13 | 513 / 527 |
adrenal gland | 100% | 692.30 | 258 / 258 | 97% | 10.44 | 222 / 230 |
ovary | 100% | 705.29 | 180 / 180 | 96% | 8.68 | 414 / 430 |
skin | 100% | 998.32 | 1809 / 1809 | 94% | 14.54 | 442 / 472 |
adipose | 100% | 859.06 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.10 | 29 / 29 |
spleen | 100% | 524.90 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 703.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 586.67 | 802 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 14.51 | 44 / 45 |
heart | 93% | 434.28 | 803 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 609.36 | 857 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 81% | 8.75 | 65 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006281 | Biological process | DNA repair |
GO_0016447 | Biological process | somatic recombination of immunoglobulin gene segments |
GO_0051096 | Biological process | positive regulation of helicase activity |
GO_0006298 | Biological process | mismatch repair |
GO_0006312 | Biological process | mitotic recombination |
GO_0043570 | Biological process | maintenance of DNA repeat elements |
GO_0045910 | Biological process | negative regulation of DNA recombination |
GO_0016020 | Cellular component | membrane |
GO_0032302 | Cellular component | MutSbeta complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0032142 | Molecular function | single guanine insertion binding |
GO_0140664 | Molecular function | ATP-dependent DNA damage sensor activity |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0032181 | Molecular function | dinucleotide repeat insertion binding |
GO_0032137 | Molecular function | guanine/thymine mispair binding |
GO_0030983 | Molecular function | mismatched DNA binding |
GO_0032139 | Molecular function | dinucleotide insertion or deletion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0032357 | Molecular function | oxidized purine DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MSH3 |
Protein name | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MutS homolog 3 |
Synonyms | DUC1 DUG |
Description | FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
Accessions | ENST00000658259.1 ENST00000667069.1 P20585 ENST00000265081.7 ENST00000659302.1 A0A590UJN8 A0A590UJW0 A0A590UK39 ENST00000670357.1 A0A590UKC9 |