MKRN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MKRN2 at tissue level.

III. Associated gene sets

GO_0006351Biological processDNA-templated transcription
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007283Biological processspermatogenesis
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0000209Biological processprotein polyubiquitination
GO_0030154Biological processcell differentiation
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMKRN2
Protein nameE3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase makorin-2)
Makorin ring finger protein 2
E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)
SynonymsRNF62
HSPC070
DescriptionFUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). .

AccessionsENST00000411987.5 [Q9H000-2]
ENST00000676701.1
A0A7I2V5D2
ENST00000677798.1
ENST00000677816.1 [Q9H000-1]
ENST00000448482.1
A0A7I2V4L9
ENST00000170447.12 [Q9H000-1]
ENST00000677142.1
A0A7I2V422
ENST00000679143.1
A0A7I2V388
A0A7I2YQI0
ENST00000676541.1
Q9H000
C9J494