Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmablast | 6 studies | 46% ± 23% | |
T cell | 6 studies | 48% ± 8% | |
B cell | 5 studies | 30% ± 5% | |
pro-B cell | 5 studies | 25% ± 3% | |
natural killer cell | 5 studies | 36% ± 17% | |
CD8-positive, alpha-beta T cell | 5 studies | 49% ± 15% | |
transit amplifying cell | 4 studies | 40% ± 11% | |
epithelial cell | 4 studies | 27% ± 13% | |
effector CD8-positive, alpha-beta T cell | 4 studies | 50% ± 23% | |
CD4-positive, alpha-beta T cell | 4 studies | 58% ± 10% | |
plasma cell | 3 studies | 34% ± 2% | |
hematopoietic precursor cell | 3 studies | 26% ± 3% | |
erythrocyte | 3 studies | 35% ± 15% |
Insufficient scRNA-seq data for expression of MKI67 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 94% | 5376.33 | 1693 / 1809 | 92% | 26.13 | 435 / 472 |
lung | 79% | 843.94 | 455 / 578 | 87% | 32.03 | 1008 / 1155 |
intestine | 57% | 1743.23 | 549 / 966 | 98% | 51.45 | 518 / 527 |
stomach | 53% | 1164.10 | 190 / 359 | 99% | 59.55 | 284 / 286 |
esophagus | 45% | 2011.10 | 652 / 1445 | 100% | 76.23 | 183 / 183 |
bladder | 24% | 153.19 | 5 / 21 | 93% | 35.88 | 471 / 504 |
uterus | 12% | 91.83 | 20 / 170 | 98% | 49.99 | 449 / 459 |
breast | 20% | 148.92 | 91 / 459 | 89% | 30.95 | 991 / 1118 |
ovary | 9% | 125.90 | 16 / 180 | 92% | 28.57 | 396 / 430 |
lymph node | 0% | 0 | 0 / 0 | 100% | 55.97 | 29 / 29 |
tonsil | 0% | 0 | 0 / 0 | 100% | 73.63 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.30 | 1 / 1 |
spleen | 100% | 2730.56 | 240 / 241 | 0% | 0 | 0 / 0 |
pancreas | 9% | 49.48 | 28 / 328 | 83% | 17.45 | 147 / 178 |
peripheral blood | 66% | 7826.54 | 616 / 929 | 0% | 0 | 0 / 0 |
adrenal gland | 53% | 388.26 | 137 / 258 | 12% | 2.65 | 28 / 230 |
liver | 19% | 207.07 | 42 / 226 | 44% | 7.29 | 178 / 406 |
prostate | 34% | 201.73 | 83 / 245 | 21% | 3.05 | 106 / 502 |
brain | 1% | 9.10 | 35 / 2642 | 41% | 8.67 | 288 / 705 |
kidney | 21% | 241.60 | 19 / 89 | 20% | 3.05 | 181 / 901 |
thymus | 18% | 125.45 | 119 / 653 | 17% | 9.26 | 102 / 605 |
adipose | 32% | 264.20 | 386 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 20% | 1.93 | 16 / 80 |
blood vessel | 18% | 104.38 | 237 / 1335 | 0% | 0 | 0 / 0 |
heart | 12% | 82.15 | 102 / 861 | 0% | 0 | 0 / 0 |
muscle | 1% | 4.91 | 10 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008283 | Biological process | cell population proliferation |
GO_0051983 | Biological process | regulation of chromosome segregation |
GO_1902275 | Biological process | regulation of chromatin organization |
GO_0007088 | Biological process | regulation of mitotic nuclear division |
GO_0005730 | Cellular component | nucleolus |
GO_0005694 | Cellular component | chromosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000793 | Cellular component | condensed chromosome |
GO_0016604 | Cellular component | nuclear body |
GO_0016020 | Cellular component | membrane |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | MKI67 |
Protein name | KI67 Antigen Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) |
Synonyms | |
Description | FUNCTION: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface . Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility . Binds DNA, with a preference for supercoiled DNA and AT-rich DNA . Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization . It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). . |
Accessions | Q70L72 Q70L73 Q70L74 ENST00000368654.8 [P46013-1] P46013 ENST00000368653.7 [P46013-2] |