MKI67 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MKI67 at tissue level.

III. Associated gene sets

GO_0008283Biological processcell population proliferation
GO_0051983Biological processregulation of chromosome segregation
GO_1902275Biological processregulation of chromatin organization
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005730Cellular componentnucleolus
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0016604Cellular componentnuclear body
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMKI67
Protein nameKI67 Antigen
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Synonyms
DescriptionFUNCTION: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface . Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility . Binds DNA, with a preference for supercoiled DNA and AT-rich DNA . Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization . It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). .

AccessionsQ70L72
Q70L73
Q70L74
ENST00000368654.8 [P46013-1]
P46013
ENST00000368653.7 [P46013-2]