MINDY2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0006508Biological processproteolysis
GO_0008150Biological processbiological_process
GO_0005654Cellular componentnucleoplasm
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0071795Molecular functionK11-linked polyubiquitin modification-dependent protein binding
GO_0071796Molecular functionK6-linked polyubiquitin modification-dependent protein binding
GO_0016807Molecular functioncysteine-type carboxypeptidase activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_1990380Molecular functionK48-linked deubiquitinase activity

IV. Literature review

[source]
Gene nameMINDY2
Protein nameUbiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B)
SynonymshCG_40045
FAM63B
KIAA1164
DescriptionFUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins . Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' . May play a regulatory role at the level of protein turnover . .

FUNCTION: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. .

FUNCTION: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. .

AccessionsENST00000316848.9
J3KNL7
H0YM15
ENST00000560289.5
Q8NBR6
ENST00000450403.3 [Q8NBR6-2]
ENST00000559228.6 [Q8NBR6-1]