MID2 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	35% ± 8%	Explore
glutamatergic neuron	3 studies	37% ± 10%	Explore
endothelial cell of lymphatic vessel	3 studies	20% ± 3%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	26% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	644.73	245 / 245	100%	17.29	501 / 502
breast	100%	646.13	459 / 459	99%	15.25	1106 / 1118
adrenal gland	100%	681.52	258 / 258	97%	11.00	223 / 230
thymus	100%	636.13	653 / 653	97%	13.33	585 / 605
pancreas	100%	273.39	327 / 328	97%	11.14	172 / 178
kidney	100%	354.70	89 / 89	95%	8.42	853 / 901
lung	100%	575.06	577 / 578	94%	9.11	1090 / 1155
esophagus	100%	704.88	1445 / 1445	92%	10.17	169 / 183
uterus	100%	765.64	170 / 170	90%	6.91	413 / 459
bladder	100%	697.10	21 / 21	83%	5.30	418 / 504
ovary	100%	459.10	180 / 180	74%	4.22	319 / 430
liver	87%	207.22	196 / 226	86%	5.51	350 / 406
stomach	100%	411.66	359 / 359	67%	4.53	192 / 286
brain	82%	185.11	2170 / 2642	85%	6.06	596 / 705
intestine	91%	474.38	881 / 966	62%	3.26	328 / 527
skin	100%	898.47	1809 / 1809	53%	5.72	251 / 472
adipose	100%	764.71	1204 / 1204	0%	0	0 / 0
blood vessel	100%	711.67	1335 / 1335	0%	0	0 / 0
muscle	100%	710.48	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.26	45 / 45
ureter	0%	0	0 / 0	100%	5.17	1 / 1
spleen	86%	184.63	208 / 241	0%	0	0 / 0
heart	77%	154.25	659 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	35%	1.76	28 / 80
lymph node	0%	0	0 / 0	24%	0.97	7 / 29
peripheral blood	11%	17.54	100 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016567	Biological process	protein ubiquitination
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045087	Biological process	innate immune response
GO_0046597	Biological process	negative regulation of viral entry into host cell
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0035372	Biological process	protein localization to microtubule
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0010508	Biological process	positive regulation of autophagy
GO_0044790	Biological process	suppression of viral release by host
GO_0032897	Biological process	negative regulation of viral transcription
GO_0005874	Cellular component	microtubule
GO_0070062	Cellular component	extracellular exosome
GO_0005737	Cellular component	cytoplasm
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0016740	Molecular function	transferase activity
GO_0008270	Molecular function	zinc ion binding
GO_0008017	Molecular function	microtubule binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0051219	Molecular function	phosphoprotein binding

Gene name	MID2
Protein name	Midline 2 Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
Synonyms	TRIM1 FXY2 RNF60
Description	FUNCTION: E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 . .
Accessions	ENST00000443968.2 [Q9UJV3-2] ENST00000451923.1 A6PVI4 ENST00000262843.11 [Q9UJV3-1] Q9UJV3

MID2 report