METTL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009048Biological processdosage compensation by inactivation of X chromosome
GO_0031053Biological processprimary miRNA processing
GO_0007283Biological processspermatogenesis
GO_1903679Biological processpositive regulation of cap-independent translational initiation
GO_0006397Biological processmRNA processing
GO_0045580Biological processregulation of T cell differentiation
GO_0051445Biological processregulation of meiotic cell cycle
GO_0034644Biological processcellular response to UV
GO_0045087Biological processinnate immune response
GO_0006974Biological processDNA damage response
GO_0001510Biological processRNA methylation
GO_0061157Biological processmRNA destabilization
GO_0007623Biological processcircadian rhythm
GO_0021861Biological processforebrain radial glial cell differentiation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0019827Biological processstem cell population maintenance
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_0042063Biological processgliogenesis
GO_0016556Biological processmRNA modification
GO_0098508Biological processendothelial to hematopoietic transition
GO_0045727Biological processpositive regulation of translation
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0048477Biological processoogenesis
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005634Cellular componentnucleus
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0003729Molecular functionmRNA binding
GO_0016422Molecular functionmRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO_0008173Molecular functionRNA methyltransferase activity
GO_0001734Molecular functionmRNA m(6)A methyltransferase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMETTL3
Protein nameMethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit (cDNA FLJ57780, highly similar to N6-adenosine-methyltransferase 70 kDa subunit)
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit (cDNA FLJ58857, highly similar to N6-adenosine-methyltransferase 70 kDa subunit)
SynonymsMTA70
DescriptionFUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing . In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core . N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing . M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation . In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism . M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites . M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB . M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) . Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist . M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 . Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm . Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation . During human coronorivus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses . .

AccessionsENST00000544248.1
H0YFV6
ENST00000539760.5
A0A0G2JH39
B4E349
Q86U44
ENST00000543235.5
F5H6D8
ENST00000537163.5
ENST00000377543.3
ENST00000298717.9 [Q86U44-1]
B4DTN4