MEOX2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MEOX2 at tissue level.

III. Associated gene sets

GO_0090051Biological processnegative regulation of cell migration involved in sprouting angiogenesis
GO_0001525Biological processangiogenesis
GO_0007519Biological processskeletal muscle tissue development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0061053Biological processsomite development
GO_0060173Biological processlimb development
GO_0001757Biological processsomite specification
GO_0060021Biological processroof of mouth development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMEOX2
Protein nameMEOX2 protein
Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)
SynonymsGAX
MOX2
DescriptionFUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis . Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation . While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner . Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). .

AccessionsENST00000262041.6
P50222
Q6FHY5