Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 33% ± 15% | |
oligodendrocyte | 11 studies | 36% ± 11% | |
glutamatergic neuron | 9 studies | 44% ± 25% | |
oligodendrocyte precursor cell | 9 studies | 29% ± 12% | |
endothelial cell | 8 studies | 32% ± 9% | |
microglial cell | 7 studies | 25% ± 7% | |
macrophage | 6 studies | 26% ± 7% | |
fibroblast | 6 studies | 24% ± 7% | |
GABAergic neuron | 6 studies | 44% ± 19% | |
neuron | 5 studies | 37% ± 18% | |
interneuron | 5 studies | 41% ± 22% | |
adipocyte | 5 studies | 22% ± 5% | |
smooth muscle cell | 5 studies | 18% ± 2% | |
retinal rod cell | 4 studies | 22% ± 3% | |
pericyte | 4 studies | 22% ± 7% | |
GABAergic interneuron | 3 studies | 19% ± 4% | |
granule cell | 3 studies | 32% ± 16% | |
cardiac muscle cell | 3 studies | 19% ± 2% | |
epithelial cell | 3 studies | 32% ± 11% | |
glycinergic amacrine cell | 3 studies | 18% ± 4% | |
retinal cone cell | 3 studies | 24% ± 10% | |
dendritic cell | 3 studies | 20% ± 3% | |
abnormal cell | 3 studies | 23% ± 6% | |
alveolar macrophage | 3 studies | 23% ± 6% | |
endothelial cell of lymphatic vessel | 3 studies | 23% ± 4% | |
monocyte | 3 studies | 21% ± 3% | |
type I pneumocyte | 3 studies | 18% ± 4% | |
lymphocyte | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 915.13 | 1445 / 1445 | 100% | 17.44 | 183 / 183 |
lung | 100% | 846.10 | 578 / 578 | 100% | 16.81 | 1155 / 1155 |
ovary | 100% | 718.08 | 180 / 180 | 100% | 18.02 | 430 / 430 |
prostate | 100% | 973.86 | 245 / 245 | 100% | 15.95 | 502 / 502 |
skin | 100% | 1092.69 | 1809 / 1809 | 100% | 17.19 | 472 / 472 |
stomach | 100% | 610.97 | 359 / 359 | 100% | 13.26 | 286 / 286 |
uterus | 100% | 1033.29 | 170 / 170 | 100% | 20.34 | 459 / 459 |
brain | 100% | 773.01 | 2638 / 2642 | 100% | 22.45 | 705 / 705 |
intestine | 100% | 822.43 | 966 / 966 | 100% | 14.71 | 526 / 527 |
thymus | 100% | 768.52 | 652 / 653 | 100% | 19.62 | 604 / 605 |
breast | 100% | 898.87 | 459 / 459 | 100% | 15.22 | 1114 / 1118 |
adrenal gland | 100% | 817.53 | 258 / 258 | 100% | 16.51 | 229 / 230 |
kidney | 100% | 717.57 | 89 / 89 | 99% | 9.88 | 896 / 901 |
bladder | 100% | 959.00 | 21 / 21 | 99% | 16.17 | 500 / 504 |
pancreas | 95% | 289.56 | 311 / 328 | 99% | 13.56 | 177 / 178 |
liver | 97% | 309.53 | 219 / 226 | 96% | 7.52 | 391 / 406 |
adipose | 100% | 814.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1434.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 16.06 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.26 | 29 / 29 |
spleen | 100% | 839.98 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 22.44 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.43 | 1 / 1 |
muscle | 100% | 687.38 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 676.79 | 850 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 548.24 | 874 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051123 | Biological process | RNA polymerase II preinitiation complex assembly |
GO_0016567 | Biological process | protein ubiquitination |
GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
GO_0006367 | Biological process | transcription initiation at RNA polymerase II promoter |
GO_0035019 | Biological process | somatic stem cell population maintenance |
GO_0032968 | Biological process | positive regulation of transcription elongation by RNA polymerase II |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0005730 | Cellular component | nucleolus |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0016592 | Cellular component | mediator complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0070847 | Cellular component | core mediator complex |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MED27 |
Protein name | Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (Mediator complex subunit 27) Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34) |
Synonyms | CRSP8 CRSP34 |
Description | FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. . |
Accessions | A0A494C0K7 ENST00000474263.1 [Q6P2C8-4] Q6P2C8 A0A494C0P0 ENST00000651555.1 U4Q365 ENST00000292035.10 [Q6P2C8-1] ENST00000651950.1 ENST00000357028.6 [Q6P2C8-2] |