MCU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032024Biological processpositive regulation of insulin secretion
GO_0051259Biological processprotein complex oligomerization
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_0036444Biological processcalcium import into the mitochondrion
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0019722Biological processcalcium-mediated signaling
GO_0042593Biological processglucose homeostasis
GO_0051561Biological processpositive regulation of mitochondrial calcium ion concentration
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_1990246Cellular componentuniplex complex
GO_0034704Cellular componentcalcium channel complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0015292Molecular functionuniporter activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameMCU
Protein nameCalcium uniporter protein
Mitochondrial calcium uniporter
Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)
SynonymsC10orf42
CCDC109A
DescriptionFUNCTION: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) . Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells . participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). .

FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. .

AccessionsENST00000603649.5
S4R332
S4R468
ENST00000373053.8 [Q8NE86-1]
S4R3W8
ENST00000605597.5
ENST00000604679.5
ENST00000604152.1
ENST00000536019.5 [Q8NE86-3]
ENST00000604372.5
Q8NE86
ENST00000357157.10 [Q8NE86-2]
S4R3F5
S4R319