Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 31% ± 13% | |
oligodendrocyte precursor cell | 10 studies | 27% ± 11% | |
glutamatergic neuron | 9 studies | 39% ± 19% | |
pericyte | 9 studies | 28% ± 11% | |
ciliated cell | 9 studies | 33% ± 18% | |
epithelial cell | 8 studies | 33% ± 16% | |
macrophage | 7 studies | 25% ± 7% | |
fibroblast | 7 studies | 23% ± 6% | |
GABAergic neuron | 7 studies | 37% ± 16% | |
astrocyte | 6 studies | 31% ± 13% | |
interneuron | 6 studies | 35% ± 14% | |
endothelial cell of lymphatic vessel | 6 studies | 38% ± 5% | |
type I pneumocyte | 6 studies | 48% ± 16% | |
smooth muscle cell | 6 studies | 25% ± 6% | |
mast cell | 5 studies | 26% ± 7% | |
club cell | 5 studies | 34% ± 13% | |
type II pneumocyte | 5 studies | 45% ± 7% | |
oligodendrocyte | 5 studies | 28% ± 10% | |
squamous epithelial cell | 4 studies | 35% ± 19% | |
granule cell | 4 studies | 35% ± 16% | |
microglial cell | 4 studies | 23% ± 6% | |
GABAergic interneuron | 3 studies | 23% ± 7% | |
neuron | 3 studies | 25% ± 9% | |
alveolar macrophage | 3 studies | 26% ± 7% | |
monocyte | 3 studies | 28% ± 5% | |
lymphocyte | 3 studies | 20% ± 3% | |
basal cell | 3 studies | 43% ± 23% | |
goblet cell | 3 studies | 40% ± 27% | |
transit amplifying cell | 3 studies | 39% ± 32% | |
mucus secreting cell | 3 studies | 29% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 2135.45 | 966 / 966 | 100% | 54.16 | 527 / 527 |
esophagus | 100% | 1471.91 | 1444 / 1445 | 100% | 59.64 | 183 / 183 |
lung | 100% | 2085.91 | 577 / 578 | 100% | 40.42 | 1155 / 1155 |
stomach | 100% | 2024.81 | 359 / 359 | 100% | 62.84 | 285 / 286 |
ovary | 100% | 945.67 | 180 / 180 | 100% | 26.88 | 428 / 430 |
kidney | 100% | 1466.60 | 89 / 89 | 99% | 29.41 | 895 / 901 |
uterus | 100% | 1705.83 | 170 / 170 | 99% | 29.37 | 454 / 459 |
breast | 100% | 1277.13 | 459 / 459 | 99% | 21.03 | 1105 / 1118 |
bladder | 100% | 1497.95 | 21 / 21 | 99% | 29.03 | 497 / 504 |
thymus | 100% | 1056.04 | 651 / 653 | 97% | 15.23 | 589 / 605 |
prostate | 100% | 948.66 | 244 / 245 | 96% | 13.59 | 482 / 502 |
pancreas | 94% | 666.36 | 308 / 328 | 99% | 46.55 | 176 / 178 |
brain | 94% | 1319.76 | 2479 / 2642 | 96% | 10.48 | 676 / 705 |
adrenal gland | 100% | 926.47 | 257 / 258 | 85% | 9.90 | 196 / 230 |
skin | 100% | 1907.80 | 1808 / 1809 | 80% | 9.00 | 377 / 472 |
liver | 95% | 592.69 | 215 / 226 | 76% | 10.12 | 307 / 406 |
muscle | 100% | 3868.13 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1131.77 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.14 | 1 / 1 |
blood vessel | 100% | 2002.41 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 1455.77 | 1203 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 22.50 | 44 / 45 |
peripheral blood | 97% | 1272.80 | 898 / 929 | 0% | 0 | 0 / 0 |
heart | 96% | 819.26 | 823 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 9.87 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 33% | 2.97 | 26 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032024 | Biological process | positive regulation of insulin secretion |
GO_0051259 | Biological process | protein complex oligomerization |
GO_0006851 | Biological process | mitochondrial calcium ion transmembrane transport |
GO_0036444 | Biological process | calcium import into the mitochondrion |
GO_0051560 | Biological process | mitochondrial calcium ion homeostasis |
GO_0090141 | Biological process | positive regulation of mitochondrial fission |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0042593 | Biological process | glucose homeostasis |
GO_0051561 | Biological process | positive regulation of mitochondrial calcium ion concentration |
GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
GO_1990246 | Cellular component | uniplex complex |
GO_0034704 | Cellular component | calcium channel complex |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0015292 | Molecular function | uniporter activity |
GO_0005515 | Molecular function | protein binding |
GO_0005262 | Molecular function | calcium channel activity |
Gene name | MCU |
Protein name | Calcium uniporter protein Mitochondrial calcium uniporter Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A) |
Synonyms | C10orf42 CCDC109A |
Description | FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) . Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells . participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). . FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. . |
Accessions | ENST00000603649.5 S4R332 S4R468 ENST00000373053.8 [Q8NE86-1] S4R3W8 ENST00000605597.5 ENST00000604679.5 ENST00000604152.1 ENST00000536019.5 [Q8NE86-3] ENST00000604372.5 Q8NE86 ENST00000357157.10 [Q8NE86-2] S4R3F5 S4R319 |