Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 23% ± 5% | |
epithelial cell | 7 studies | 34% ± 18% | |
basal cell | 7 studies | 27% ± 11% | |
fibroblast | 7 studies | 21% ± 4% | |
astrocyte | 6 studies | 28% ± 9% | |
adipocyte | 5 studies | 20% ± 4% | |
glutamatergic neuron | 5 studies | 42% ± 10% | |
macrophage | 4 studies | 22% ± 7% | |
pericyte | 4 studies | 23% ± 8% | |
GABAergic neuron | 4 studies | 33% ± 7% | |
oligodendrocyte precursor cell | 4 studies | 34% ± 20% | |
interneuron | 4 studies | 40% ± 16% | |
oligodendrocyte | 4 studies | 27% ± 11% | |
squamous epithelial cell | 3 studies | 35% ± 22% | |
conventional dendritic cell | 3 studies | 26% ± 5% | |
non-classical monocyte | 3 studies | 20% ± 4% | |
ciliated cell | 3 studies | 29% ± 4% | |
dendritic cell | 3 studies | 27% ± 6% | |
endothelial cell of lymphatic vessel | 3 studies | 23% ± 9% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 17% ± 2% | |
neuron | 3 studies | 31% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 3033.91 | 459 / 459 | 100% | 47.92 | 1118 / 1118 |
esophagus | 100% | 2675.80 | 1445 / 1445 | 100% | 30.71 | 183 / 183 |
prostate | 100% | 2652.22 | 245 / 245 | 100% | 49.58 | 502 / 502 |
brain | 100% | 1790.71 | 2638 / 2642 | 100% | 36.49 | 705 / 705 |
lung | 100% | 2576.68 | 577 / 578 | 100% | 34.77 | 1155 / 1155 |
intestine | 100% | 1989.46 | 966 / 966 | 100% | 27.73 | 526 / 527 |
ovary | 100% | 2965.93 | 180 / 180 | 100% | 32.19 | 429 / 430 |
bladder | 100% | 2173.57 | 21 / 21 | 100% | 31.34 | 502 / 504 |
thymus | 100% | 2811.29 | 653 / 653 | 100% | 37.72 | 602 / 605 |
uterus | 100% | 2623.34 | 170 / 170 | 99% | 35.25 | 456 / 459 |
stomach | 100% | 1795.98 | 359 / 359 | 99% | 25.97 | 284 / 286 |
liver | 100% | 1670.44 | 226 / 226 | 99% | 19.15 | 401 / 406 |
pancreas | 100% | 1223.06 | 327 / 328 | 99% | 24.47 | 176 / 178 |
adrenal gland | 100% | 3062.52 | 258 / 258 | 98% | 22.50 | 226 / 230 |
kidney | 100% | 2177.51 | 89 / 89 | 98% | 23.19 | 885 / 901 |
skin | 100% | 2302.82 | 1808 / 1809 | 94% | 19.47 | 444 / 472 |
adipose | 100% | 2728.15 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.63 | 29 / 29 |
muscle | 100% | 2294.00 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1833.17 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 33.54 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.62 | 1 / 1 |
blood vessel | 100% | 1968.96 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1807.29 | 847 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 1658.41 | 887 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 15.34 | 74 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051865 | Biological process | protein autoubiquitination |
GO_0070585 | Biological process | protein localization to mitochondrion |
GO_0090141 | Biological process | positive regulation of mitochondrial fission |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0090140 | Biological process | regulation of mitochondrial fission |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0051020 | Molecular function | GTPase binding |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | MARCHF5 |
Protein name | E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5) |
Synonyms | MARCH5 RNF153 |
Description | FUNCTION: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. . |
Accessions | ENST00000358935.3 Q9NX47 |