MARCHF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051865Biological processprotein autoubiquitination
GO_0070585Biological processprotein localization to mitochondrion
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0000209Biological processprotein polyubiquitination
GO_0090140Biological processregulation of mitochondrial fission
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0051020Molecular functionGTPase binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMARCHF5
Protein nameE3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)
SynonymsMARCH5
RNF153
DescriptionFUNCTION: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. .

AccessionsENST00000358935.3
Q9NX47