MARCHF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0002495Biological processantigen processing and presentation of peptide antigen via MHC class II
GO_0000209Biological processprotein polyubiquitination
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0031902Cellular componentlate endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042287Molecular functionMHC protein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMARCHF1
Protein nameMembrane associated ring-CH-type finger 1
Membrane associated ring-CH-type finger 1 (cDNA FLJ57628, highly similar to Homo sapiens membrane-associated ring finger (C3HC4) 1 (MARCH1), mRNA)
E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1)
SynonymsRNF171
MARCH1
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. .

AccessionsENST00000339875.9 [Q8TCQ1-2]
Q8TCQ1
ENST00000503008.5 [Q8TCQ1-1]
D6RGC4
B7Z739
ENST00000510786.1
ENST00000274056.11 [Q8TCQ1-1]
ENST00000507270.5
ENST00000514618.6
D6REN1