Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 33 studies | 40% ± 15% | |
macrophage | 29 studies | 36% ± 17% | |
conventional dendritic cell | 22 studies | 30% ± 13% | |
classical monocyte | 20 studies | 32% ± 13% | |
naive B cell | 17 studies | 34% ± 8% | |
non-classical monocyte | 17 studies | 32% ± 11% | |
memory B cell | 16 studies | 37% ± 8% | |
dendritic cell | 15 studies | 39% ± 18% | |
monocyte | 14 studies | 39% ± 16% | |
oligodendrocyte | 14 studies | 79% ± 21% | |
microglial cell | 14 studies | 56% ± 18% | |
glutamatergic neuron | 12 studies | 63% ± 25% | |
oligodendrocyte precursor cell | 11 studies | 78% ± 20% | |
myeloid cell | 11 studies | 36% ± 10% | |
GABAergic neuron | 10 studies | 50% ± 18% | |
plasmacytoid dendritic cell | 10 studies | 26% ± 9% | |
retinal rod cell | 8 studies | 63% ± 35% | |
astrocyte | 7 studies | 45% ± 21% | |
retinal cone cell | 7 studies | 69% ± 30% | |
mononuclear phagocyte | 6 studies | 39% ± 15% | |
neuron | 5 studies | 46% ± 19% | |
interneuron | 5 studies | 52% ± 26% | |
mesothelial cell | 4 studies | 37% ± 13% | |
amacrine cell | 4 studies | 66% ± 20% | |
retinal ganglion cell | 4 studies | 52% ± 28% | |
alveolar macrophage | 4 studies | 39% ± 12% | |
leukocyte | 3 studies | 27% ± 13% | |
endothelial cell | 3 studies | 47% ± 9% | |
tissue-resident macrophage | 3 studies | 37% ± 13% | |
GABAergic amacrine cell | 3 studies | 46% ± 13% | |
glycinergic amacrine cell | 3 studies | 60% ± 11% | |
neutrophil | 3 studies | 33% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1021.68 | 2637 / 2642 | 100% | 13.27 | 704 / 705 |
breast | 100% | 813.13 | 459 / 459 | 99% | 5.42 | 1104 / 1118 |
lung | 100% | 1194.69 | 577 / 578 | 98% | 5.34 | 1136 / 1155 |
esophagus | 99% | 517.68 | 1430 / 1445 | 94% | 3.42 | 172 / 183 |
pancreas | 99% | 453.41 | 324 / 328 | 92% | 3.86 | 164 / 178 |
ovary | 99% | 729.93 | 178 / 180 | 90% | 3.03 | 389 / 430 |
uterus | 100% | 847.77 | 170 / 170 | 86% | 2.45 | 393 / 459 |
bladder | 100% | 583.05 | 21 / 21 | 84% | 2.79 | 425 / 504 |
thymus | 99% | 639.51 | 648 / 653 | 81% | 2.20 | 490 / 605 |
kidney | 85% | 399.11 | 76 / 89 | 94% | 5.77 | 845 / 901 |
stomach | 97% | 440.97 | 348 / 359 | 81% | 3.13 | 233 / 286 |
skin | 98% | 648.08 | 1781 / 1809 | 78% | 3.29 | 366 / 472 |
intestine | 99% | 870.77 | 960 / 966 | 75% | 2.21 | 393 / 527 |
prostate | 100% | 673.34 | 244 / 245 | 71% | 1.51 | 356 / 502 |
adrenal gland | 100% | 542.38 | 257 / 258 | 39% | 0.77 | 90 / 230 |
liver | 92% | 311.05 | 208 / 226 | 40% | 0.93 | 162 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.76 | 29 / 29 |
spleen | 100% | 3138.44 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 945.87 | 1199 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 764.22 | 1324 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 1304.23 | 894 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 3.43 | 37 / 45 |
heart | 72% | 248.71 | 619 / 861 | 0% | 0 | 0 / 0 |
muscle | 46% | 124.15 | 371 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 34% | 0.68 | 27 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006955 | Biological process | immune response |
GO_0002495 | Biological process | antigen processing and presentation of peptide antigen via MHC class II |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0032588 | Cellular component | trans-Golgi network membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0031901 | Cellular component | early endosome membrane |
GO_0005764 | Cellular component | lysosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005768 | Cellular component | endosome |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0031902 | Cellular component | late endosome membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005886 | Cellular component | plasma membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0042287 | Molecular function | MHC protein binding |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | MARCHF1 |
Protein name | Membrane associated ring-CH-type finger 1 Membrane associated ring-CH-type finger 1 (cDNA FLJ57628, highly similar to Homo sapiens membrane-associated ring finger (C3HC4) 1 (MARCH1), mRNA) E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1) |
Synonyms | RNF171 MARCH1 |
Description | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. . |
Accessions | ENST00000339875.9 [Q8TCQ1-2] Q8TCQ1 ENST00000503008.5 [Q8TCQ1-1] D6RGC4 B7Z739 ENST00000510786.1 ENST00000274056.11 [Q8TCQ1-1] ENST00000507270.5 ENST00000514618.6 D6REN1 |