MAP4K2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAP4K2 at tissue level.

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0006955Biological processimmune response
GO_0007254Biological processJNK cascade
GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0006903Biological processvesicle targeting
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0016323Cellular componentbasolateral plasma membrane
GO_0000139Cellular componentGolgi membrane
GO_0005737Cellular componentcytoplasm
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0008349Molecular functionMAP kinase kinase kinase kinase activity

IV. Literature review

[source]
Gene nameMAP4K2
Protein nameMitogen-activated protein kinase kinase kinase kinase 2
Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsGCK
RAB8IP
DescriptionFUNCTION: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. .

AccessionsENST00000439069.5
ENST00000433890.5
ENST00000424945.5
ENST00000435926.5
ENST00000444560.1
H7C208
ENST00000294066.7 [Q12851-1]
Q12851
F2Z2B3
ENST00000377350.7 [Q12851-2]
C9JCU6
F8WCP4