MAML1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	7 studies	23% ± 9%	Explore
mast cell	4 studies	25% ± 8%	Explore
glutamatergic neuron	4 studies	30% ± 15%	Explore
interneuron	4 studies	30% ± 16%	Explore
microglial cell	4 studies	23% ± 2%	Explore
oligodendrocyte	4 studies	21% ± 3%	Explore
epithelial cell	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	18% ± 3%	Explore
macrophage	3 studies	19% ± 4%	Explore
astrocyte	3 studies	26% ± 4%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 2%	Explore

Name	Number of supported studies	Average coverage
brain	6 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4592.00	1445 / 1445	100%	48.24	183 / 183
breast	100%	4428.83	459 / 459	100%	41.72	1116 / 1118
stomach	100%	3307.31	359 / 359	100%	35.16	285 / 286
intestine	100%	4671.60	966 / 966	100%	32.78	525 / 527
prostate	100%	4905.17	245 / 245	100%	33.96	500 / 502
lung	100%	4242.17	578 / 578	100%	32.19	1150 / 1155
ovary	100%	5728.24	180 / 180	100%	36.75	428 / 430
bladder	100%	4670.52	21 / 21	99%	28.07	501 / 504
skin	100%	4191.20	1809 / 1809	99%	30.55	468 / 472
thymus	100%	4740.94	653 / 653	99%	31.60	599 / 605
pancreas	100%	2509.64	327 / 328	99%	27.61	176 / 178
uterus	100%	5775.28	170 / 170	98%	34.81	452 / 459
brain	98%	2541.79	2598 / 2642	100%	26.36	702 / 705
kidney	100%	3001.06	89 / 89	95%	22.01	855 / 901
adrenal gland	100%	4421.44	258 / 258	94%	18.98	216 / 230
liver	100%	1667.85	226 / 226	80%	11.60	325 / 406
adipose	100%	4193.83	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4167.08	1335 / 1335	0%	0	0 / 0
spleen	100%	4919.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	37.05	45 / 45
ureter	0%	0	0 / 0	100%	7.48	1 / 1
muscle	100%	2257.07	802 / 803	0%	0	0 / 0
heart	100%	2251.36	858 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	20.44	78 / 80
lymph node	0%	0	0 / 0	97%	22.31	28 / 29
peripheral blood	96%	2923.60	888 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007221	Biological process	positive regulation of transcription of Notch receptor target
GO_0006468	Biological process	protein phosphorylation
GO_0003162	Biological process	atrioventricular node development
GO_0060928	Biological process	atrioventricular node cell development
GO_0007219	Biological process	Notch signaling pathway
GO_0045445	Biological process	myoblast differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0010831	Biological process	positive regulation of myotube differentiation
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0002193	Cellular component	MAML1-RBP-Jkappa- ICN1 complex
GO_0005634	Cellular component	nucleus
GO_0042605	Molecular function	peptide antigen binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding

Gene name	MAML1
Protein name	Mastermind-like protein 1 (Mam-1)
Synonyms	KIAA0200
Description	FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. .
Accessions	ENST00000638220.2 ENST00000292599.4 Q92585

MAML1 report