Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 15 studies | 50% ± 20% | |
| endothelial cell | 15 studies | 41% ± 17% | |
| oligodendrocyte precursor cell | 14 studies | 59% ± 17% | |
| oligodendrocyte | 13 studies | 37% ± 19% | |
| glutamatergic neuron | 12 studies | 82% ± 15% | |
| microglial cell | 12 studies | 43% ± 19% | |
| GABAergic neuron | 11 studies | 70% ± 20% | |
| type II pneumocyte | 9 studies | 65% ± 23% | |
| adipocyte | 9 studies | 43% ± 11% | |
| epithelial cell | 8 studies | 34% ± 20% | |
| smooth muscle cell | 8 studies | 30% ± 10% | |
| type I pneumocyte | 7 studies | 44% ± 18% | |
| neuron | 7 studies | 50% ± 22% | |
| fibroblast | 7 studies | 29% ± 15% | |
| interneuron | 6 studies | 72% ± 19% | |
| retinal ganglion cell | 6 studies | 71% ± 34% | |
| B cell | 6 studies | 20% ± 4% | |
| basal cell | 6 studies | 49% ± 25% | |
| club cell | 6 studies | 46% ± 23% | |
| retinal bipolar neuron | 5 studies | 54% ± 32% | |
| macrophage | 5 studies | 33% ± 16% | |
| cardiac muscle cell | 5 studies | 44% ± 9% | |
| ciliated cell | 5 studies | 40% ± 15% | |
| hepatocyte | 4 studies | 50% ± 24% | |
| granule cell | 4 studies | 67% ± 12% | |
| mesothelial cell | 4 studies | 44% ± 17% | |
| Mueller cell | 4 studies | 41% ± 19% | |
| OFF-bipolar cell | 4 studies | 77% ± 28% | |
| ON-bipolar cell | 4 studies | 76% ± 33% | |
| amacrine cell | 4 studies | 64% ± 12% | |
| retina horizontal cell | 4 studies | 64% ± 21% | |
| retinal cone cell | 4 studies | 74% ± 16% | |
| retinal rod cell | 4 studies | 58% ± 25% | |
| cholangiocyte | 3 studies | 37% ± 13% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 58% ± 10% | |
| GABAergic interneuron | 3 studies | 78% ± 14% | |
| GABAergic amacrine cell | 3 studies | 81% ± 10% | |
| glycinergic amacrine cell | 3 studies | 57% ± 7% | |
| rod bipolar cell | 3 studies | 78% ± 30% | |
| retinal pigment epithelial cell | 3 studies | 32% ± 11% | |
| endothelial cell of lymphatic vessel | 3 studies | 34% ± 14% | |
| respiratory goblet cell | 3 studies | 45% ± 14% | |
| mucus secreting cell | 3 studies | 39% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 534.58 | 243 / 245 | 93% | 3.26 | 469 / 502 |
| ovary | 98% | 343.83 | 176 / 180 | 86% | 4.92 | 371 / 430 |
| thymus | 93% | 226.71 | 607 / 653 | 89% | 8.50 | 540 / 605 |
| brain | 99% | 1063.77 | 2627 / 2642 | 71% | 2.23 | 501 / 705 |
| kidney | 99% | 340.26 | 88 / 89 | 65% | 3.03 | 589 / 901 |
| lung | 99% | 1498.36 | 570 / 578 | 63% | 4.91 | 731 / 1155 |
| breast | 84% | 221.41 | 387 / 459 | 65% | 2.21 | 724 / 1118 |
| adrenal gland | 97% | 296.15 | 250 / 258 | 51% | 1.36 | 118 / 230 |
| uterus | 96% | 424.40 | 163 / 170 | 47% | 2.74 | 215 / 459 |
| bladder | 86% | 300.76 | 18 / 21 | 46% | 3.30 | 234 / 504 |
| skin | 74% | 272.50 | 1330 / 1809 | 50% | 2.08 | 237 / 472 |
| stomach | 85% | 205.87 | 304 / 359 | 36% | 1.33 | 103 / 286 |
| pancreas | 38% | 52.85 | 126 / 328 | 80% | 3.47 | 143 / 178 |
| intestine | 83% | 208.67 | 798 / 966 | 33% | 1.32 | 174 / 527 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.30 | 1 / 1 |
| esophagus | 67% | 134.17 | 967 / 1445 | 27% | 1.38 | 50 / 183 |
| blood vessel | 81% | 400.85 | 1082 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 80% | 199.69 | 960 / 1204 | 0% | 0 | 0 / 0 |
| liver | 43% | 62.05 | 98 / 226 | 35% | 1.51 | 144 / 406 |
| spleen | 76% | 203.44 | 184 / 241 | 0% | 0 | 0 / 0 |
| muscle | 64% | 107.52 | 516 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 59% | 14.73 | 17 / 29 |
| heart | 39% | 57.56 | 337 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 33% | 0.66 | 26 / 80 |
| peripheral blood | 23% | 1045.32 | 214 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 0.53 | 10 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007420 | Biological process | brain development |
| GO_0042278 | Biological process | purine nucleoside metabolic process |
| GO_0006974 | Biological process | DNA damage response |
| GO_0051725 | Biological process | protein de-ADP-ribosylation |
| GO_0140291 | Biological process | peptidyl-glutamate ADP-deribosylation |
| GO_0009617 | Biological process | response to bacterium |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140293 | Molecular function | ADP-ribosylglutamate hydrolase activity |
| GO_0019213 | Molecular function | deacetylase activity |
| GO_0016798 | Molecular function | hydrolase activity, acting on glycosyl bonds |
| Gene name | MACROD2 |
| Protein name | ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-) Mono-ADP ribosylhydrolase 2 |
| Synonyms | C20orf133 |
| Description | FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety . Inactive towards proteins bearing poly-ADP-ribose . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . . |
| Accessions | ENST00000217246.8 [A1Z1Q3-2] ENST00000407045.3 [A1Z1Q3-6] ENST00000684519.1 [A1Z1Q3-1] A1Z1Q3 A0A2R8YFN3 ENST00000642719.1 ENST00000402914.5 [A1Z1Q3-4] |