Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 13 studies | 25% ± 11% | |
| oligodendrocyte precursor cell | 9 studies | 30% ± 12% | |
| fibroblast | 8 studies | 21% ± 6% | |
| glutamatergic neuron | 7 studies | 42% ± 25% | |
| pericyte | 6 studies | 23% ± 6% | |
| B cell | 6 studies | 20% ± 7% | |
| macrophage | 6 studies | 23% ± 5% | |
| epithelial cell | 6 studies | 33% ± 16% | |
| ciliated cell | 6 studies | 23% ± 5% | |
| oligodendrocyte | 6 studies | 22% ± 5% | |
| conventional dendritic cell | 5 studies | 27% ± 9% | |
| connective tissue cell | 5 studies | 23% ± 6% | |
| neuron | 5 studies | 36% ± 14% | |
| microglial cell | 5 studies | 24% ± 3% | |
| GABAergic neuron | 5 studies | 39% ± 19% | |
| astrocyte | 5 studies | 30% ± 7% | |
| endothelial cell of lymphatic vessel | 4 studies | 21% ± 5% | |
| interneuron | 4 studies | 35% ± 18% | |
| hematopoietic precursor cell | 3 studies | 28% ± 9% | |
| progenitor cell | 3 studies | 22% ± 5% | |
| neural crest cell | 3 studies | 18% ± 3% | |
| smooth muscle cell | 3 studies | 20% ± 4% | |
| naive B cell | 3 studies | 18% ± 1% | |
| granule cell | 3 studies | 17% ± 1% | |
| myeloid cell | 3 studies | 19% ± 3% | |
| dendritic cell | 3 studies | 38% ± 13% | |
| intestinal crypt stem cell | 3 studies | 19% ± 2% | |
| basal cell | 3 studies | 33% ± 4% | |
| transit amplifying cell | 3 studies | 27% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1186.66 | 2642 / 2642 | 100% | 24.47 | 705 / 705 |
| ovary | 100% | 1519.46 | 180 / 180 | 100% | 31.58 | 430 / 430 |
| prostate | 100% | 999.46 | 245 / 245 | 100% | 20.28 | 502 / 502 |
| skin | 100% | 1169.25 | 1809 / 1809 | 100% | 35.52 | 472 / 472 |
| stomach | 100% | 805.01 | 359 / 359 | 100% | 18.72 | 286 / 286 |
| thymus | 100% | 1232.62 | 653 / 653 | 100% | 23.33 | 605 / 605 |
| lung | 100% | 931.48 | 577 / 578 | 100% | 22.21 | 1155 / 1155 |
| bladder | 100% | 1110.38 | 21 / 21 | 100% | 21.46 | 503 / 504 |
| uterus | 100% | 1347.49 | 170 / 170 | 100% | 22.82 | 458 / 459 |
| breast | 100% | 1501.23 | 459 / 459 | 100% | 20.61 | 1115 / 1118 |
| liver | 100% | 509.55 | 226 / 226 | 100% | 16.78 | 404 / 406 |
| intestine | 100% | 1001.27 | 965 / 966 | 99% | 21.07 | 524 / 527 |
| pancreas | 100% | 682.27 | 327 / 328 | 99% | 15.68 | 177 / 178 |
| esophagus | 100% | 978.79 | 1445 / 1445 | 99% | 14.06 | 181 / 183 |
| adrenal gland | 100% | 1376.28 | 258 / 258 | 99% | 22.03 | 227 / 230 |
| kidney | 100% | 938.80 | 89 / 89 | 98% | 14.96 | 887 / 901 |
| adipose | 100% | 1472.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 38.95 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 55.07 | 29 / 29 |
| spleen | 100% | 1785.54 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.64 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.82 | 1 / 1 |
| blood vessel | 100% | 1082.26 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 835.55 | 856 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 469.31 | 783 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 72% | 551.90 | 673 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016226 | Biological process | iron-sulfur cluster assembly |
| GO_0044572 | Biological process | [4Fe-4S] cluster assembly |
| GO_0044571 | Biological process | [2Fe-2S] cluster assembly |
| GO_1990229 | Cellular component | iron-sulfur cluster assembly complex |
| GO_0099128 | Cellular component | mitochondrial [2Fe-2S] assembly complex |
| GO_0016604 | Cellular component | nuclear body |
| GO_1990221 | Cellular component | L-cysteine desulfurase complex |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LYRM4 |
| Protein name | LYR motif-containing protein 4 LYR motif containing 4 |
| Synonyms | C6orf149 CGI-203 ISD11 |
| Description | FUNCTION: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU . The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 . . |
| Accessions | Q9HD34 ENST00000480566.5 ENST00000464010.5 ENST00000463032.5 ENST00000468929.5 C9JRX8 C9J799 ENST00000330636.9 ENST00000500576.4 F5H189 H7C4Q5 C9JY28 |