LYRM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016226Biological processiron-sulfur cluster assembly
GO_0044572Biological process[4Fe-4S] cluster assembly
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_1990229Cellular componentiron-sulfur cluster assembly complex
GO_0099128Cellular componentmitochondrial [2Fe-2S] assembly complex
GO_0016604Cellular componentnuclear body
GO_1990221Cellular componentL-cysteine desulfurase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLYRM4
Protein nameLYR motif-containing protein 4
LYR motif containing 4
SynonymsC6orf149
CGI-203
ISD11
DescriptionFUNCTION: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU . The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 . .

AccessionsQ9HD34
ENST00000480566.5
ENST00000464010.5
ENST00000463032.5
ENST00000468929.5
C9JRX8
C9J799
ENST00000330636.9
ENST00000500576.4
F5H189
H7C4Q5
C9JY28