I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 23% ± 6% | |
| GABAergic neuron | 3 studies | 26% ± 5% | |
| glutamatergic neuron | 3 studies | 29% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 23% ± 6% | |
| GABAergic neuron | 3 studies | 26% ± 5% | |
| glutamatergic neuron | 3 studies | 29% ± 6% |
Insufficient scRNA-seq data for expression of LRRC4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 2824.44 | 2601 / 2642 | 99% | 44.56 | 700 / 705 |
| adrenal gland | 92% | 694.09 | 237 / 258 | 68% | 9.25 | 156 / 230 |
| ovary | 69% | 556.25 | 125 / 180 | 66% | 8.13 | 284 / 430 |
| lung | 65% | 371.37 | 373 / 578 | 62% | 17.98 | 711 / 1155 |
| kidney | 87% | 436.10 | 77 / 89 | 36% | 2.64 | 324 / 901 |
| uterus | 47% | 278.22 | 80 / 170 | 50% | 9.42 | 231 / 459 |
| spleen | 95% | 786.61 | 230 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 40% | 255.02 | 578 / 1445 | 46% | 14.33 | 84 / 183 |
| peripheral blood | 71% | 1600.05 | 660 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 11.45 | 26 / 45 |
| heart | 52% | 223.96 | 448 / 861 | 0% | 0 | 0 / 0 |
| stomach | 42% | 186.86 | 151 / 359 | 9% | 0.49 | 27 / 286 |
| breast | 10% | 27.15 | 44 / 459 | 27% | 1.58 | 297 / 1118 |
| thymus | 7% | 22.93 | 44 / 653 | 29% | 3.63 | 174 / 605 |
| intestine | 21% | 63.78 | 202 / 966 | 9% | 0.59 | 45 / 527 |
| adipose | 28% | 89.66 | 336 / 1204 | 0% | 0 | 0 / 0 |
| skin | 3% | 10.18 | 60 / 1809 | 24% | 1.81 | 114 / 472 |
| bladder | 5% | 12.48 | 1 / 21 | 15% | 1.88 | 77 / 504 |
| prostate | 16% | 46.59 | 40 / 245 | 4% | 0.27 | 18 / 502 |
| eye | 0% | 0 | 0 / 0 | 19% | 0.86 | 15 / 80 |
| pancreas | 0% | 0.83 | 1 / 328 | 12% | 1.28 | 21 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.64 | 3 / 29 |
| liver | 9% | 28.42 | 20 / 226 | 1% | 0.04 | 4 / 406 |
| blood vessel | 8% | 33.16 | 112 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 8% | 23.03 | 61 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097119 | Biological process | postsynaptic density protein 95 clustering |
| GO_0099560 | Biological process | synaptic membrane adhesion |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_1904861 | Biological process | excitatory synapse assembly |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0060076 | Cellular component | excitatory synapse |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LRRC4 |
| Protein name | Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2) Leucine rich repeat containing 4 |
| Synonyms | UNQ554/PRO1111 NAG14 BAG |
| Description | FUNCTION: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). . |
| Accessions | ENST00000478726.1 ENST00000249363.4 C9J7K7 C9JA92 C9J7V8 ENST00000494115.1 ENST00000476782.5 Q9HBW1 |
