LPCAT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061024Biological processmembrane organization
GO_0036151Biological processphosphatidylcholine acyl-chain remodeling
GO_0006663Biological processplatelet activating factor biosynthetic process
GO_0005795Cellular componentGolgi stack
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0047144Molecular function2-acylglycerol-3-phosphate O-acyltransferase activity
GO_0047192Molecular function1-alkylglycerophosphocholine O-acetyltransferase activity
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0047159Molecular functionplasmalogen synthase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0047184Molecular function1-acylglycerophosphocholine O-acyltransferase activity
GO_0042171Molecular functionlysophosphatidic acid acyltransferase activity

IV. Literature review

[source]
Gene nameLPCAT2
Protein nameLysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha)
Lysophosphatidylcholine acyltransferase 2
SynonymsAYTL1
AGPAT11
DescriptionFUNCTION: Exhibits both acyltransferase and acetyltransferase activities . Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) . Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone . Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) . Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size . .

AccessionsENST00000564084.1
Q7L5N7
H3BU68
ENST00000262134.10 [Q7L5N7-1]