LPCAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036148Biological processphosphatidylglycerol acyl-chain remodeling
GO_0036151Biological processphosphatidylcholine acyl-chain remodeling
GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0060041Biological processretina development in camera-type eye
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0008654Biological processphospholipid biosynthetic process
GO_0043129Biological processsurfactant homeostasis
GO_0030163Biological processprotein catabolic process
GO_2001246Biological processnegative regulation of phosphatidylcholine biosynthetic process
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0047192Molecular function1-alkylglycerophosphocholine O-acetyltransferase activity
GO_0047144Molecular function2-acylglycerol-3-phosphate O-acyltransferase activity
GO_0042171Molecular functionlysophosphatidic acid acyltransferase activity
GO_0047191Molecular function1-alkylglycerophosphocholine O-acyltransferase activity
GO_0047159Molecular functionplasmalogen synthase activity
GO_0005509Molecular functioncalcium ion binding
GO_0047184Molecular function1-acylglycerophosphocholine O-acyltransferase activity

IV. Literature review

[source]
Gene nameLPCAT1
Protein nameLysophosphatidylcholine acyltransferase 1
Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3)
SynonymsPFAAP3
AYTL2
DescriptionFUNCTION: Exhibits acyltransferase activity . Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) . Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size . .

AccessionsQ8NF37
A0A0G2JRI7
ENST00000626646.1
ENST00000611696.3
ENST00000283415.4
ENST00000625809.2
A0A0G2JQ62
ENST00000475622.5