Name | Number of supported studies | Average coverage | |
---|---|---|---|
CD8-positive, alpha-beta T cell | 8 studies | 27% ± 10% | |
CD4-positive, alpha-beta T cell | 6 studies | 30% ± 11% | |
natural killer cell | 6 studies | 29% ± 10% | |
B cell | 5 studies | 25% ± 3% | |
pro-B cell | 5 studies | 30% ± 4% | |
T cell | 5 studies | 28% ± 9% | |
plasmablast | 4 studies | 39% ± 18% | |
hematopoietic precursor cell | 4 studies | 29% ± 8% | |
GABAergic neuron | 4 studies | 20% ± 1% | |
glutamatergic neuron | 4 studies | 21% ± 2% | |
effector CD8-positive, alpha-beta T cell | 4 studies | 23% ± 3% | |
mast cell | 3 studies | 21% ± 4% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 21% ± 1% | |
classical monocyte | 3 studies | 25% ± 8% | |
conventional dendritic cell | 3 studies | 38% ± 6% | |
epithelial cell | 3 studies | 33% ± 4% | |
dendritic cell | 3 studies | 37% ± 3% | |
transit amplifying cell | 3 studies | 38% ± 3% | |
regulatory T cell | 3 studies | 23% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 1046.19 | 574 / 578 | 95% | 53.96 | 1102 / 1155 |
skin | 97% | 1765.47 | 1757 / 1809 | 92% | 48.91 | 434 / 472 |
ovary | 81% | 342.33 | 146 / 180 | 95% | 51.98 | 409 / 430 |
breast | 72% | 320.14 | 331 / 459 | 96% | 65.66 | 1078 / 1118 |
intestine | 66% | 1079.64 | 634 / 966 | 98% | 85.14 | 514 / 527 |
stomach | 63% | 490.52 | 227 / 359 | 99% | 73.29 | 282 / 286 |
uterus | 62% | 247.56 | 105 / 170 | 98% | 117.61 | 450 / 459 |
esophagus | 55% | 832.70 | 788 / 1445 | 97% | 54.57 | 178 / 183 |
bladder | 52% | 235.62 | 11 / 21 | 96% | 72.52 | 485 / 504 |
liver | 81% | 360.50 | 184 / 226 | 56% | 19.25 | 226 / 406 |
brain | 59% | 383.90 | 1560 / 2642 | 76% | 35.50 | 533 / 705 |
pancreas | 43% | 141.50 | 141 / 328 | 90% | 31.85 | 161 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 128.81 | 29 / 29 |
peripheral blood | 100% | 7278.24 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 2150.76 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 130.82 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.15 | 1 / 1 |
prostate | 54% | 213.38 | 133 / 245 | 41% | 10.20 | 207 / 502 |
thymus | 54% | 235.53 | 355 / 653 | 40% | 26.47 | 239 / 605 |
kidney | 39% | 209.85 | 35 / 89 | 40% | 9.32 | 359 / 901 |
adipose | 78% | 473.39 | 943 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 51% | 186.76 | 131 / 258 | 13% | 4.71 | 29 / 230 |
blood vessel | 34% | 140.42 | 454 / 1335 | 0% | 0 | 0 / 0 |
heart | 20% | 86.35 | 174 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 13% | 1.97 | 10 / 80 |
muscle | 9% | 46.29 | 72 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051664 | Biological process | nuclear pore localization |
GO_0006998 | Biological process | nuclear envelope organization |
GO_0090435 | Biological process | protein localization to nuclear envelope |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0031507 | Biological process | heterochromatin formation |
GO_0007097 | Biological process | nuclear migration |
GO_0016020 | Cellular component | membrane |
GO_0005638 | Cellular component | lamin filament |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005637 | Cellular component | nuclear inner membrane |
GO_0005635 | Cellular component | nuclear envelope |
GO_0016363 | Cellular component | nuclear matrix |
GO_0005652 | Cellular component | nuclear lamina |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005634 | Cellular component | nucleus |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0005200 | Molecular function | structural constituent of cytoskeleton |
GO_0043274 | Molecular function | phospholipase binding |
GO_0160123 | Molecular function | structural constituent of nuclear lamina |
GO_0005515 | Molecular function | protein binding |
Gene name | LMNB1 |
Protein name | LMNB1 protein Lamin B1 Alternative protein LMNB1 Lamin-B1 |
Synonyms | hCG_27033 LMN2 LMNB |
Description | FUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane . Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics . The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively . . |
Accessions | A0A0D9SFY5 ENST00000261366.10 ENST00000460265.5 A0A0D9SFE5 L0R6K0 E9PBF6 Q6DC98 ENST00000395354.1 P20700 ENST00000492190.5 |