LMNB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051664Biological processnuclear pore localization
GO_0006998Biological processnuclear envelope organization
GO_0090435Biological processprotein localization to nuclear envelope
GO_0007010Biological processcytoskeleton organization
GO_0031507Biological processheterochromatin formation
GO_0007097Biological processnuclear migration
GO_0016020Cellular componentmembrane
GO_0005638Cellular componentlamin filament
GO_0005654Cellular componentnucleoplasm
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0016363Cellular componentnuclear matrix
GO_0005652Cellular componentnuclear lamina
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0043274Molecular functionphospholipase binding
GO_0160123Molecular functionstructural constituent of nuclear lamina
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLMNB1
Protein nameLMNB1 protein
Lamin B1
Alternative protein LMNB1
Lamin-B1
SynonymshCG_27033
LMN2
LMNB
DescriptionFUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane . Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics . The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively . .

AccessionsA0A0D9SFY5
ENST00000261366.10
ENST00000460265.5
A0A0D9SFE5
L0R6K0
E9PBF6
Q6DC98
ENST00000395354.1
P20700
ENST00000492190.5