LIPA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	43% ± 19%	Explore
endothelial cell	20 studies	26% ± 9%	Explore
non-classical monocyte	19 studies	30% ± 10%	Explore
oligodendrocyte	16 studies	49% ± 17%	Explore
classical monocyte	15 studies	25% ± 11%	Explore
microglial cell	11 studies	29% ± 13%	Explore
myeloid cell	11 studies	38% ± 18%	Explore
monocyte	10 studies	27% ± 12%	Explore
glutamatergic neuron	9 studies	35% ± 21%	Explore
alveolar macrophage	8 studies	42% ± 15%	Explore
conventional dendritic cell	8 studies	32% ± 12%	Explore
GABAergic neuron	7 studies	34% ± 18%	Explore
mononuclear phagocyte	6 studies	33% ± 16%	Explore
capillary endothelial cell	6 studies	17% ± 1%	Explore
interneuron	6 studies	35% ± 21%	Explore
endothelial cell of vascular tree	6 studies	19% ± 2%	Explore
neuron	5 studies	30% ± 19%	Explore
endothelial cell of artery	5 studies	20% ± 3%	Explore
enterocyte	5 studies	23% ± 3%	Explore
epithelial cell	5 studies	31% ± 13%	Explore
dendritic cell	5 studies	30% ± 14%	Explore
astrocyte	5 studies	31% ± 11%	Explore
leukocyte	4 studies	26% ± 3%	Explore
granule cell	4 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	4 studies	28% ± 5%	Explore
basal cell	4 studies	23% ± 5%	Explore
natural killer cell	4 studies	16% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 3%	Explore
GABAergic interneuron	3 studies	20% ± 5%	Explore
tissue-resident macrophage	3 studies	46% ± 24%	Explore
retina horizontal cell	3 studies	22% ± 3%	Explore
intermediate monocyte	3 studies	37% ± 7%	Explore
myofibroblast cell	3 studies	18% ± 4%	Explore
inflammatory macrophage	3 studies	36% ± 13%	Explore
fibroblast	3 studies	23% ± 7%	Explore
vein endothelial cell	3 studies	17% ± 1%	Explore
connective tissue cell	3 studies	19% ± 1%	Explore
B cell	3 studies	17% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 2%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	33% ± 16%	Explore
lung	8 studies	19% ± 4%	Explore
peripheral blood	6 studies	19% ± 3%	Explore
liver	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2184.19	1440 / 1445	100%	55.76	183 / 183
breast	100%	6281.20	459 / 459	99%	79.34	1110 / 1118
lung	100%	6329.03	578 / 578	99%	93.17	1144 / 1155
brain	99%	3530.52	2610 / 2642	100%	83.40	702 / 705
kidney	100%	2554.78	89 / 89	97%	124.94	874 / 901
intestine	100%	3473.65	963 / 966	97%	52.75	511 / 527
thymus	99%	2492.12	648 / 653	97%	49.75	587 / 605
liver	98%	2728.98	221 / 226	98%	63.66	396 / 406
skin	98%	3852.58	1770 / 1809	97%	85.65	460 / 472
uterus	99%	2770.74	169 / 170	94%	44.07	433 / 459
bladder	100%	2734.81	21 / 21	93%	52.52	470 / 504
stomach	96%	1780.59	345 / 359	97%	63.48	277 / 286
ovary	98%	2265.54	176 / 180	95%	41.47	407 / 430
adrenal gland	100%	4343.44	258 / 258	92%	53.52	211 / 230
prostate	98%	1987.17	241 / 245	92%	40.27	464 / 502
pancreas	89%	1501.15	292 / 328	98%	66.20	174 / 178
adipose	100%	8433.02	1204 / 1204	0%	0	0 / 0
spleen	100%	19125.59	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	16.16	1 / 1
blood vessel	99%	3099.43	1325 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	54.22	43 / 45
peripheral blood	93%	3129.51	867 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	108.03	27 / 29
eye	0%	0	0 / 0	91%	42.93	73 / 80
heart	86%	1415.91	744 / 861	0%	0	0 / 0
muscle	30%	328.38	244 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007040	Biological process	lysosome organization
GO_0050862	Biological process	positive regulation of T cell receptor signaling pathway
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0030324	Biological process	lung development
GO_0140962	Biological process	multicellular organismal-level chemical homeostasis
GO_0000278	Biological process	mitotic cell cycle
GO_0006897	Biological process	endocytosis
GO_0140354	Biological process	lipid import into cell
GO_0033028	Biological process	myeloid cell apoptotic process
GO_0006096	Biological process	glycolytic process
GO_0042098	Biological process	T cell proliferation
GO_0006754	Biological process	ATP biosynthetic process
GO_0008340	Biological process	determination of adult lifespan
GO_0030421	Biological process	defecation
GO_0048539	Biological process	bone marrow development
GO_0031929	Biological process	TOR signaling
GO_0071830	Biological process	triglyceride-rich lipoprotein particle clearance
GO_0070341	Biological process	fat cell proliferation
GO_0033189	Biological process	response to vitamin A
GO_0002526	Biological process	acute inflammatory response
GO_0016125	Biological process	sterol metabolic process
GO_0006631	Biological process	fatty acid metabolic process
GO_0002021	Biological process	response to dietary excess
GO_1990845	Biological process	adaptive thermogenesis
GO_0070231	Biological process	T cell apoptotic process
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0010878	Biological process	cholesterol storage
GO_0016042	Biological process	lipid catabolic process
GO_0048536	Biological process	spleen development
GO_0071838	Biological process	cell proliferation in bone marrow
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0048771	Biological process	tissue remodeling
GO_0030217	Biological process	T cell differentiation
GO_0007005	Biological process	mitochondrion organization
GO_0042159	Biological process	lipoprotein catabolic process
GO_0006776	Biological process	vitamin A metabolic process
GO_1903409	Biological process	reactive oxygen species biosynthetic process
GO_0030099	Biological process	myeloid cell differentiation
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0008333	Biological process	endosome to lysosome transport
GO_0009409	Biological process	response to cold
GO_0001935	Biological process	endothelial cell proliferation
GO_0002536	Biological process	respiratory burst involved in inflammatory response
GO_0006641	Biological process	triglyceride metabolic process
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0061519	Biological process	macrophage homeostasis
GO_0072576	Biological process	liver morphogenesis
GO_0035726	Biological process	common myeloid progenitor cell proliferation
GO_0060612	Biological process	adipose tissue development
GO_0010467	Biological process	gene expression
GO_0000902	Biological process	cell morphogenesis
GO_0097384	Biological process	cellular lipid biosynthetic process
GO_0055088	Biological process	lipid homeostasis
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0033344	Biological process	cholesterol efflux
GO_0060837	Biological process	blood vessel endothelial cell differentiation
GO_0006695	Biological process	cholesterol biosynthetic process
GO_1901355	Biological process	response to rapamycin
GO_0006006	Biological process	glucose metabolic process
GO_0005764	Cellular component	lysosome
GO_0005654	Cellular component	nucleoplasm
GO_0001650	Cellular component	fibrillar center
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0043202	Cellular component	lysosomal lumen
GO_0004771	Molecular function	sterol esterase activity
GO_0016298	Molecular function	lipase activity

IV. Literature review

[source]

Gene name	LIPA
Protein name	Lipase A, lysosomal acid type Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase)
Synonyms
Description	FUNCTION: Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. .
Accessions	Q5T770 A0A0A0MT32 ENST00000336233.10 [P38571-1] ENST00000282673.5 ENST00000428800.5 Q5T073 P38571 ENST00000371837.5 [P38571-2] ENST00000456827.5

LIPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review