LILRA4 | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	25 studies	76% ± 20%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LILRA4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	71%	69.87	1875 / 2642	68%	4.36	476 / 705
lung	89%	58.50	515 / 578	35%	0.83	399 / 1155
spleen	100%	1155.15	241 / 241	0%	0	0 / 0
peripheral blood	98%	414.62	910 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	65.40	25 / 29
breast	25%	7.76	114 / 459	51%	1.66	573 / 1118
kidney	11%	3.74	10 / 89	48%	1.65	428 / 901
tonsil	0%	0	0 / 0	47%	1.30	21 / 45
intestine	39%	37.58	376 / 966	7%	0.20	39 / 527
skin	16%	4.17	283 / 1809	30%	1.44	143 / 472
pancreas	4%	0.87	14 / 328	29%	0.87	52 / 178
adipose	30%	8.74	365 / 1204	0%	0	0 / 0
bladder	19%	9.71	4 / 21	10%	0.28	50 / 504
prostate	13%	4.27	33 / 245	12%	0.22	62 / 502
thymus	8%	3.66	50 / 653	18%	0.88	107 / 605
stomach	7%	1.82	26 / 359	13%	0.30	37 / 286
liver	16%	5.80	36 / 226	4%	0.11	17 / 406
uterus	3%	0.75	5 / 170	16%	0.34	74 / 459
adrenal gland	14%	2.69	36 / 258	1%	0.01	2 / 230
blood vessel	14%	7.64	193 / 1335	0%	0	0 / 0
esophagus	6%	1.77	93 / 1445	8%	0.18	14 / 183
eye	0%	0	0 / 0	14%	0.41	11 / 80
ovary	2%	0.41	4 / 180	7%	0.13	30 / 430
heart	7%	1.78	63 / 861	0%	0	0 / 0
muscle	0%	0.08	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0038095	Biological process	Fc-epsilon receptor signaling pathway
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0032687	Biological process	negative regulation of interferon-alpha production
GO_0034156	Biological process	negative regulation of toll-like receptor 7 signaling pathway
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_0045087	Biological process	innate immune response
GO_0034164	Biological process	negative regulation of toll-like receptor 9 signaling pathway
GO_0032998	Cellular component	Fc-epsilon receptor I complex
GO_0005886	Cellular component	plasma membrane
GO_0015026	Molecular function	coreceptor activity
GO_0032396	Molecular function	inhibitory MHC class I receptor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

Gene name	LILRA4
Protein name	Leukocyte immunoglobulin like receptor A4 Leukocyte immunoglobulin-like receptor subfamily A member 4 Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)
Synonyms	ILT7
Description	FUNCTION: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G . Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades . Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells . Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) . Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells . .
Accessions	A0A075B7A5 P59901 ENST00000595581.1 ENST00000291759.5 [P59901-1] ENST00000619832.1 A0A0G2JNG2 ENST00000620539.4 ENST00000616790.1 ENST00000613813.1

LILRA4 report