LGI1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	13 studies	46% ± 21%	Explore
glutamatergic neuron	6 studies	43% ± 27%	Explore
GABAergic neuron	5 studies	48% ± 19%	Explore
retinal pigment epithelial cell	3 studies	37% ± 17%	Explore
interneuron	3 studies	58% ± 22%	Explore

Name	Number of supported studies	Average coverage
brain	7 studies	34% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	3303.16	2584 / 2642	76%	4.12	539 / 705
intestine	49%	266.92	470 / 966	0%	0	0 / 527
blood vessel	37%	179.20	495 / 1335	0%	0	0 / 0
muscle	20%	102.21	164 / 803	0%	0	0 / 0
adrenal gland	3%	13.16	7 / 258	17%	0.40	38 / 230
stomach	17%	102.26	62 / 359	1%	0.02	3 / 286
liver	9%	35.24	20 / 226	1%	0.08	4 / 406
bladder	10%	50.14	2 / 21	0%	0.00	1 / 504
prostate	2%	12.32	6 / 245	4%	0.25	19 / 502
esophagus	4%	20.23	64 / 1445	1%	0.01	1 / 183
uterus	1%	1.65	1 / 170	4%	0.17	17 / 459
breast	0%	0	0 / 459	4%	0.18	41 / 1118
pancreas	0%	0	0 / 328	3%	0.10	5 / 178
adipose	2%	7.29	24 / 1204	0%	0	0 / 0
skin	0%	0.84	5 / 1809	1%	0.03	5 / 472
ovary	1%	1.57	1 / 180	1%	0.07	3 / 430
lung	0%	0	0 / 578	1%	0.05	12 / 1155
heart	1%	3.60	8 / 861	0%	0	0 / 0
kidney	0%	0	0 / 89	1%	0.05	8 / 901
thymus	0%	0.64	1 / 653	0%	0.01	1 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050806	Biological process	positive regulation of synaptic transmission
GO_0007399	Biological process	nervous system development
GO_0030307	Biological process	positive regulation of cell growth
GO_0099645	Biological process	neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0007411	Biological process	axon guidance
GO_0031175	Biological process	neuron projection development
GO_0043083	Cellular component	synaptic cleft
GO_0005615	Cellular component	extracellular space
GO_0098978	Cellular component	glutamatergic synapse
GO_0005783	Cellular component	endoplasmic reticulum
GO_0030425	Cellular component	dendrite
GO_0005576	Cellular component	extracellular region
GO_0005794	Cellular component	Golgi apparatus
GO_0043194	Cellular component	axon initial segment
GO_0005737	Cellular component	cytoplasm
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

Gene name	LGI1
Protein name	Leucine rich glioma inactivated 1 (Leucine-rich glioma inactivated 1 isoform 3) Leucine-rich glioma-inactivated protein 1 (Epitempin-1) Leucine-rich glioma-inactivated protein 1 Leucine rich glioma inactivated 1
Synonyms	hCG_2024350 EPT UNQ775/PRO1569
Description	FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. .
Accessions	ENST00000478763.2 ENST00000636946.1 O95970 A0A0D9SFH6 ENST00000638049.1 A0A0D9SFE3 ENST00000627420.2 A0A0S2Z4X3 ENST00000627699.1 A0A1B0GVP2 ENST00000371413.4 [O95970-2] A0A1B0GV33 A0A0D9SFS5 ENST00000637925.1 ENST00000636155.1 ENST00000629035.2 ENST00000371418.9 [O95970-1] ENST00000630487.2 ENST00000635953.1 ENST00000630184.2 ENST00000636754.1 ENST00000636232.1 A0A1B0GUD3 A0A0D9SFU4 ENST00000637611.1 ENST00000630047.2 [O95970-3] ENST00000637037.1 ENST00000637689.1 A0A0S2Z4S7 A0A0S2Z5G1 A0A1B0GTM5 A0A1B0GVF6 A0A1B0GWB4

LGI1 report